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Overview

Uniprot IDP07310
Protein NameCreatine kinase M-type
Gene NameCkm
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
101 QDRHGGYKPTDKHKT
107 YKPTDKHKTDLNHEN
11 GNTHNKFKLNYKPQE
116 DLNHENLKGGDDLDP
15 NKFKLNYKPQEEYPD
170 NSLTGEFKGKYYPLK
242 LRVISMEKGGNMKEV
247 MEKGGNMKEVFRRFC
25 EEYPDLSKHNNHMAK
259 RFCVGLQKIEEIFKK
265 QKIEEIFKKAGHPFM
266 KIEEIFKKAGHPFMW
298 LRGGVHVKLANLSKH
304 VKLANLSKHPKFEEI
307 ANLSKHPKFEEILTR
32 KHNNHMAKVLTPDLY
365 KLMVEMEKKLEKGQS
369 EMEKKLEKGQSIDDM
41 LTPDLYNKLRDKETP
9 PFGNTHNKFKLNYKP

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Protein Sequence

10 MPFGNTHNKF 20 KLNYKPQEEY 30 PDLSKHNNHM 40 AKVLTPDLYN 50 KLRDKETPSG 60 FTLDDVIQTG 70 VDNPGHPFIM 80 TVGCVAGDEE 90 SYTVFKDLFD 100 PIIQDRHGGY 110 KPTDKHKTDL 120 NHENLKGGDD 130 LDPNYVLSSR 140 VRTGRSIKGY 150 TLPPHCSRGE 160 RRAVEKLSVE 170 ALNSLTGEFK 180 GKYYPLKSMT 190 EQEQQQLIDD 200 HFLFDKPVSP 210 LLLASGMARD 220 WPDARGIWHN 230 DNKSFLVWVN 240 EEDHLRVISM 250 EKGGNMKEVF 260 RRFCVGLQKI 270 EEIFKKAGHP 280 FMWNEHLGYV 290 LTCPSNLGTG 300 LRGGVHVKLA 310 NLSKHPKFEE 320 ILTRLRLQKR 330 GTGGVDTAAV 340 GAVFDISNAD 350 RLGSSEVEQV 360 QLVVDGVKLM 370 VEMEKKLEKG 380 QSIDDMIPAQ K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004111 creatine kinase activity
Biological Process GO:0046314 phosphocreatine biosynthetic process
Biological Process GO:0006603 phosphocreatine metabolic process
Biological Process GO:0009408 response to heat

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.