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Overview

Uniprot IDP07323
Protein NameGamma-enolase
Gene NameEno2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
126 CKAGAAEKDLPLYRH
193 AEVYHTLKGVIKDKY
233 LVKEAIDKAGYTEKM
262 GKYDLDFKSPADPSR
335 IERAVEEKACNCLLL
406 CRSERLAKYNQLMRI
60 DKQRYLGKGVLKAVD

Function

Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (PubMed:7753500)

Protein Sequence

10 MSIQKIWARE 20 ILDSRGNPTV 30 EVDLHTAKGL 40 FRAAVPSGAS 50 TGIYEALELR 60 DGDKQRYLGK 70 GVLKAVDHIN 80 STIAPALISS 90 GLSVVEQEKL 100 DNLMLELDGT 110 ENKSKFGANA 120 ILGVSLAVCK 130 AGAAEKDLPL 140 YRHIAQLAGN 150 SDLILPVPAF 160 NVINGGSHAG 170 NKLAMQEFMI 180 LPVGAESFRD 190 AMRLGAEVYH 200 TLKGVIKDKY 210 GKDATNVGDE 220 GGFAPNILEN 230 SEALELVKEA 240 IDKAGYTEKM 250 VIGMDVAASE 260 FYRDGKYDLD 270 FKSPADPSRC 280 ITGDQLGALY 290 QDFVRNYPVV 300 SIEDPFDQDD 310 WAAWSKFTAN 320 VGIQIVGDDL 330 TVTNPKRIER 340 AVEEKACNCL 350 LLKVNQIGSV 360 TEAIQACKLA 370 QENGWGVMVS 380 HRSGETEDTF 390 IADLVVGLCT 400 GQIKTGAPCR 410 SERLAKYNQL 420 MRIEEELGEE 430 ARFAGHNFRN PSVL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030426 growth cone
Cellular Component GO:0016020 membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0000015 phosphopyruvate hydratase complex
Cellular Component GO:0001917 photoreceptor inner segment
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0097060 synaptic membrane
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004634 phosphopyruvate hydratase activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006096 glycolytic process
Biological Process GO:0032355 response to estradiol
Biological Process GO:0009410 response to xenobiotic stimulus

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.