Search Results
Overview
| Uniprot ID | P07327 |
|---|---|
| Protein Name | Alcohol dehydrogenase 1A |
| Gene Name | ADH1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | LAIPQCGKCRICKNP |
| 105 | CGKCRICKNPESNYC |
| 11 | AGKVIKCKAAVLWEL |
| 136 | SRFTCRRKPIHHFLG |
| 169 | DAASPLEKVCLIGCG |
| 20 | AVLWELKKPFSIEEV |
| 213 | LSAIMGCKAAGAARI |
| 316 | LLTGRTWKGAILGGF |
| 324 | GAILGGFKSKECVPK |
| 326 | ILGGFKSKECVPKLV |
| 33 | EVEVAPPKAHEVRIK |
| 331 | KSKECVPKLVADFMA |
| 339 | LVADFMAKKFSLDAL |
| 89 | TTVKPGDKVIPLAIP |
Function
Alcohol dehydrogenase (PubMed:2738060). Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate (PubMed:2738060)
Protein Sequence
10
MSTAGKVIKC
20
KAAVLWELKK
30
PFSIEEVEVA
40
PPKAHEVRIK
50
MVAVGICGTD
60
DHVVSGTMVT
70
PLPVILGHEA
80
AGIVESVGEG
90
VTTVKPGDKV
100
IPLAIPQCGK
110
CRICKNPESN
120
YCLKNDVSNP
130
QGTLQDGTSR
140
FTCRRKPIHH
150
FLGISTFSQY
160
TVVDENAVAK
170
IDAASPLEKV
180
CLIGCGFSTG
190
YGSAVNVAKV
200
TPGSTCAVFG
210
LGGVGLSAIM
220
GCKAAGAARI
230
IAVDINKDKF
240
AKAKELGATE
250
CINPQDYKKP
260
IQEVLKEMTD
270
GGVDFSFEVI
280
GRLDTMMASL
290
LCCHEACGTS
300
VIVGVPPDSQ
310
NLSMNPMLLL
320
TGRTWKGAIL
330
GGFKSKECVP
340
KLVADFMAKK
350
FSLDALITHV
360
LPFEKINEGF
370
DLLHSGKSIR
TILMF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004022 | alcohol dehydrogenase (NAD+) activity |
| Molecular Function | GO:0004745 | all-trans-retinol dehydrogenase (NAD+) activity |
| Molecular Function | GO:1990362 | butanol dehydrogenase (NAD+) activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006066 | alcohol metabolic process |
| Biological Process | GO:0042573 | retinoic acid metabolic process |
| Biological Process | GO:0042572 | retinol metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.