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Overview

Uniprot ID	P07332
Protein Name	Tyrosine-protein kinase Fes/Fps
Gene Name	FES
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
540	TQQPLTKKSGVVLHR

Function

Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28

Protein Sequence

10 MGFSSELCSP 20 QGHGVLQQMQ 30 EAELRLLEGM 40 RKWMAQRVKS 50 DREYAGLLHH 60 MSLQDSGGQS 70 RAISPDSPIS 80 QSWAEITSQT 90 EGLSRLLRQH 100 AEDLNSGPLS 110 KLSLLIRERQ 120 QLRKTYSEQW 130 QQLQQELTKT 140 HSQDIEKLKS 150 QYRALARDSA 160 QAKRKYQEAS 170 KDKDRDKAKD 180 KYVRSLWKLF 190 AHHNRYVLGV 200 RAAQLHHQHH 210 HQLLLPGLLR 220 SLQDLHEEMA 230 CILKEILQEY 240 LEISSLVQDE 250 VVAIHREMAA 260 AAARIQPEAE 270 YQGFLRQYGS 280 APDVPPCVTF 290 DESLLEEGEP 300 LEPGELQLNE 310 LTVESVQHTL 320 TSVTDELAVA 330 TEMVFRRQEM 340 VTQLQQELRN 350 EEENTHPRER 360 VQLLGKRQVL 370 QEALQGLQVA 380 LCSQAKLQAQ 390 QELLQTKLEH 400 LGPGEPPPVL 410 LLQDDRHSTS 420 SSEQEREGGR 430 TPTLEILKSH 440 ISGIFRPKFS 450 LPPPLQLIPE 460 VQKPLHEQLW 470 YHGAIPRAEV 480 AELLVHSGDF 490 LVRESQGKQE 500 YVLSVLWDGL 510 PRHFIIQSLD 520 NLYRLEGEGF 530 PSIPLLIDHL 540 LSTQQPLTKK 550 SGVVLHRAVP 560 KDKWVLNHED 570 LVLGEQIGRG 580 NFGEVFSGRL 590 RADNTLVAVK 600 SCRETLPPDL 610 KAKFLQEARI 620 LKQYSHPNIV 630 RLIGVCTQKQ 640 PIYIVMELVQ 650 GGDFLTFLRT 660 EGARLRVKTL 670 LQMVGDAAAG 680 MEYLESKCCI 690 HRDLAARNCL 700 VTEKNVLKIS 710 DFGMSREEAD 720 GVYAASGGLR 730 QVPVKWTAPE 740 ALNYGRYSSE 750 SDVWSFGILL 760 WETFSLGASP 770 YPNLSNQQTR 780 EFVEKGGRLP 790 CPELCPDAVF 800 RLMEQCWAYE 810 PGQRPSFSTI 820 YQELQSIRKR HR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0015630	microtubule cytoskeleton
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0034987	immunoglobulin receptor binding
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity
Molecular Function	GO:0035091	phosphatidylinositol binding
Molecular Function	GO:0004713	protein tyrosine kinase activity
Biological Process	GO:0060038	cardiac muscle cell proliferation
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0071305	cellular response to vitamin D
Biological Process	GO:0006935	chemotaxis
Biological Process	GO:0051450	myoblast proliferation
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation
Biological Process	GO:0031116	positive regulation of microtubule polymerization
Biological Process	GO:0045657	positive regulation of monocyte differentiation
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation
Biological Process	GO:0010976	positive regulation of neuron projection development
Biological Process	GO:0046777	protein autophosphorylation
Biological Process	GO:0030155	regulation of cell adhesion
Biological Process	GO:0045595	regulation of cell differentiation
Biological Process	GO:2000145	regulation of cell motility
Biological Process	GO:0042127	regulation of cell population proliferation
Biological Process	GO:0008360	regulation of cell shape
Biological Process	GO:0043304	regulation of mast cell degranulation
Biological Process	GO:0060627	regulation of vesicle-mediated transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.