Search Results

Overview

Uniprot IDP07339
Protein NameCathepsin D
Gene NameCTSD
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
122 IACWIHHKYNSDKSS
127 HHKYNSDKSSTYVKN
184 QVFGEATKQPGITFI
253 MLGGTDSKYYKGSLS
267 SYLNVTRKAYWQVHL
341 TLPAITLKLGGKGYK
345 ITLKLGGKGYKLSPE
348 KLGGKGYKLSPEDYT
357 SPEDYTLKVSQAGKT

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease

Protein Sequence

10 MQPSSLLPLA 20 LCLLAAPASA 30 LVRIPLHKFT 40 SIRRTMSEVG 50 GSVEDLIAKG 60 PVSKYSQAVP 70 AVTEGPIPEV 80 LKNYMDAQYY 90 GEIGIGTPPQ 100 CFTVVFDTGS 110 SNLWVPSIHC 120 KLLDIACWIH 130 HKYNSDKSST 140 YVKNGTSFDI 150 HYGSGSLSGY 160 LSQDTVSVPC 170 QSASSASALG 180 GVKVERQVFG 190 EATKQPGITF 200 IAAKFDGILG 210 MAYPRISVNN 220 VLPVFDNLMQ 230 QKLVDQNIFS 240 FYLSRDPDAQ 250 PGGELMLGGT 260 DSKYYKGSLS 270 YLNVTRKAYW 280 QVHLDQVEVA 290 SGLTLCKEGC 300 EAIVDTGTSL 310 MVGPVDEVRE 320 LQKAIGAVPL 330 IQGEYMIPCE 340 KVSTLPAITL 350 KLGGKGYKLS 360 PEDYTLKVSQ 370 AGKTLCLSGF 380 MGMDIPPPSG 390 PLWILGDVFI 400 GRYYTVFDRD 410 NNRVGFAEAA RL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031904 endosome lumen
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0043202 lysosomal lumen
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0005764 lysosome
Cellular Component GO:0042470 melanosome
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0035580 specific granule lumen
Cellular Component GO:1904724 tertiary granule lumen
Molecular Function GO:0004190 aspartic-type endopeptidase activity
Molecular Function GO:0070001 aspartic-type peptidase activity
Molecular Function GO:0004197 cysteine-type endopeptidase activity
Molecular Function GO:0008233 peptidase activity
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0097194 execution phase of apoptosis
Biological Process GO:1901143 insulin catabolic process
Biological Process GO:0038020 insulin receptor recycling
Biological Process GO:0042159 lipoprotein catabolic process
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0006508 proteolysis
Biological Process GO:0070201 regulation of establishment of protein localization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.