Search Results
Overview
| Uniprot ID | P07340 |
|---|---|
| Protein Name | Sodium/potassium-transporting ATPase subunit beta-1 |
| Gene Name | Atp1b1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | IRFLEKYKDSAQKDD |
| 13 | AKEEGSWKKFIWNSE |
| 14 | KEEGSWKKFIWNSEK |
| 21 | KFIWNSEKKEFLGRT |
| 217 | LPVQCTGKRDEDKDK |
| 278 | TEIRIECKAYGENIG |
| 289 | ENIGYSEKDRFQGRF |
| 7 | *MARGKAKEEGSWKK |
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:22328500). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0030315 | T-tubule |
| Molecular Function | GO:0001671 | ATPase activator activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0005391 | P-type sodium:potassium-exchanging transporter activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0141109 | transporter activator activity |
| Biological Process | GO:0046034 | ATP metabolic process |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0006883 | intracellular sodium ion homeostasis |
| Biological Process | GO:0086009 | membrane repolarization |
| Biological Process | GO:0030001 | metal ion transport |
| Biological Process | GO:1903288 | positive regulation of potassium ion import across plasma membrane |
| Biological Process | GO:1901381 | positive regulation of potassium ion transmembrane transport |
| Biological Process | GO:1903278 | positive regulation of sodium ion export across plasma membrane |
| Biological Process | GO:1902307 | positive regulation of sodium ion transmembrane transport |
| Biological Process | GO:1990573 | potassium ion import across plasma membrane |
| Biological Process | GO:0006813 | potassium ion transport |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:1903169 | regulation of calcium ion transmembrane transport |
| Biological Process | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0036376 | sodium ion export across plasma membrane |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
| Biological Process | GO:0006814 | sodium ion transport |
| Biological Process | GO:0055085 | transmembrane transport |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031090 | organelle membrane |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.