Search Results
Overview
| Uniprot ID | P07355 |
|---|---|
| Protein Name | Annexin A2 |
| Gene Name | ANXA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | TVHEILCKLSLEGDH |
| 104 | TVILGLLKTPAQYDA |
| 115 | QYDASELKASMKGLG |
| 119 | SELKASMKGLGTDED |
| 148 | QEINRVYKEMYKTDL |
| 152 | RVYKEMYKTDLEKDI |
| 157 | MYKTDLEKDIISDTS |
| 169 | DTSGDFRKLMVALAK |
| 176 | KLMVALAKGRRAEDG |
| 204 | DLYDAGVKRKGTDVP |
| 227 | RSVPHLQKVFDRYKS |
| 233 | QKVFDRYKSYSPYDM |
| 279 | DRLYDSMKGKGTRDK |
| 28 | PSAYGSVKAYTNFDA |
| 281 | LYDSMKGKGTRDKVL |
| 302 | RSEVDMLKIRSEFKR |
| 310 | IRSEFKRKYGKSLYY |
| 313 | EFKRKYGKSLYYYIQ |
| 324 | YYIQQDTKGDYQKAL |
| 47 | LNIETAIKTKGVDEV |
| 49 | IETAIKTKGVDEVTI |
| 81 | AYQRRTKKELASALK |
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Biological Process | GO:0050767 | regulation of neurogenesis |
| Biological Process | GO:0006900 | vesicle budding from membrane |
| Cellular Component | GO:1990665 | AnxA2-p11 complex |
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0035749 | myelin sheath adaxonal region |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990667 | PCSK9-AnxA2 complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0043220 | Schmidt-Lanterman incisure |
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0098641 | cadherin binding involved in cell-cell adhesion |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0019834 | phospholipase A2 inhibitor activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0044548 | S100 protein binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0001765 | membrane raft assembly |
| Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
| Biological Process | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process |
| Biological Process | GO:0002091 | negative regulation of receptor internalization |
| Biological Process | GO:0036035 | osteoclast development |
| Biological Process | GO:0045921 | positive regulation of exocytosis |
| Biological Process | GO:1905581 | positive regulation of low-density lipoprotein particle clearance |
| Biological Process | GO:1905686 | positive regulation of plasma membrane repair |
| Biological Process | GO:0010756 | positive regulation of plasminogen activation |
| Biological Process | GO:0001921 | positive regulation of receptor recycling |
| Biological Process | GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0044090 | positive regulation of vacuole organization |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
Reference
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[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[6] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[8] Hu J, Jin Z, Gao Y, Liu Q, Yu Y et al.. Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients.. J Proteome Res 24(4):1732-1744. 2025 Apr 4. PMID: 40112136.
[9] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[10] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[11] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.