Search Results
Overview
| Uniprot ID | P07356 |
|---|---|
| Protein Name | Annexin A2 |
| Gene Name | Anxa2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 152 | RVYKEMYKTDLEKDI |
| 227 | RSVCHLQKVFERYKS |
| 49 | IETAVKTKGVDEVTI |
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:22848640). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (PubMed:22453828). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (PubMed:14702107)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1990665 | AnxA2-p11 complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0019834 | phospholipase A2 inhibitor activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0044548 | S100 protein binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007589 | body fluid secretion |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0030199 | collagen fibril organization |
| Biological Process | GO:1904019 | epithelial cell apoptotic process |
| Biological Process | GO:0042730 | fibrinolysis |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0001765 | membrane raft assembly |
| Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
| Biological Process | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process |
| Biological Process | GO:0002091 | negative regulation of receptor internalization |
| Biological Process | GO:0036035 | osteoclast development |
| Biological Process | GO:0045921 | positive regulation of exocytosis |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:1905581 | positive regulation of low-density lipoprotein particle clearance |
| Biological Process | GO:1905686 | positive regulation of plasma membrane repair |
| Biological Process | GO:0010756 | positive regulation of plasminogen activation |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0001921 | positive regulation of receptor recycling |
| Biological Process | GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0044090 | positive regulation of vacuole organization |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0050767 | regulation of neurogenesis |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0006900 | vesicle budding from membrane |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0044354 | macropinosome |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0035749 | myelin sheath adaxonal region |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990667 | PCSK9-AnxA2 complex |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098797 | plasma membrane protein complex |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0043220 | Schmidt-Lanterman incisure |
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0044730 | bone sialoprotein binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.