Overview
| Uniprot ID | P07357 |
|---|
| Protein Name | Complement component C8 alpha chain |
|---|
| Gene Name | C8A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 479 |
SLGPLEAKRQNLRRA |
Function
Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:17872444, PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328, PubMed:7440581). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:17872444, PubMed:30552328, PubMed:39914456, PubMed:39814882, PubMed:7440581). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:17872444, PubMed:30552328, PubMed:7440581). C8A, together with C8B and C8G, inserts into the target membrane, but does not form pores by itself (PubMed:17872444, PubMed:30552328). During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity (PubMed:30552328, PubMed:6833260)
Protein Sequence
10
MFAVVFFILS
20
LMTCQPGVTA
30
QEKVNQRVRR
40
AATPAAVTCQ
50
LSNWSEWTDC
60
FPCQDKKYRH
70
RSLLQPNKFG
80
GTICSGDIWD
90
QASCSSSTTC
100
VRQAQCGQDF
110
QCKETGRCLK
120
RHLVCNGDQD
130
CLDGSDEDDC
140
EDVRAIDEDC
150
SQYEPIPGSQ
160
KAALGYNILT
170
QEDAQSVYDA
180
SYYGGQCETV
190
YNGEWRELRY
200
DSTCERLYYG
210
DDEKYFRKPY
220
NFLKYHFEAL
230
ADTGISSEFY
240
DNANDLLSKV
250
KKDKSDSFGV
260
TIGIGPAGSP
270
LLVGVGVSHS
280
QDTSFLNELN
290
KYNEKKFIFT
300
RIFTKVQTAH
310
FKMRKDDIML
320
DEGMLQSLME
330
LPDQYNYGMY
340
AKFINDYGTH
350
YITSGSMGGI
360
YEYILVIDKA
370
KMESLGITSR
380
DITTCFGGSL
390
GIQYEDKINV
400
GGGLSGDHCK
410
KFGGGKTERA
420
RKAMAVEDII
430
SRVRGGSSGW
440
SGGLAQNRST
450
ITYRSWGRSL
460
KYNPVVIDFE
470
MQPIHEVLRH
480
TSLGPLEAKR
490
QNLRRALDQY
500
LMEFNACRCG
510
PCFNNGVPIL
520
EGTSCRCQCR
530
LGSLGAACEQ
540
TQTEGAKADG
550
SWSCWSSWSV
560
CRAGIQERRR
570
ECDNPAPQNG
580
GASCPGRKVQ
TQAC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0072562 |
blood microparticle |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005579 |
membrane attack complex |
| Cellular Component |
GO:0044218 |
other organism cell membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0001848 |
complement binding |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Biological Process |
GO:0006956 |
complement activation |
| Biological Process |
GO:0006957 |
complement activation, alternative pathway |
| Biological Process |
GO:0006958 |
complement activation, classical pathway |
| Biological Process |
GO:0160257 |
complement activation, GZMK pathway |
| Biological Process |
GO:0006955 |
immune response |
| Biological Process |
GO:0031640 |
killing of cells of another organism |
| Biological Process |
GO:0050778 |
positive regulation of immune response |
| Biological Process |
GO:0055085 |
transmembrane transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.