Search Results
Overview
| Uniprot ID | P07384 |
|---|---|
| Protein Name | Calpain-1 catalytic subunit |
| Gene Name | CAPN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 79 | DLGPNSSKTYGIKWK |
Function
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626)
Protein Sequence
10
MSEEIITPVY
20
CTGVSAQVQK
30
QRARELGLGR
40
HENAIKYLGQ
50
DYEQLRVRCL
60
QSGTLFRDEA
70
FPPVPQSLGY
80
KDLGPNSSKT
90
YGIKWKRPTE
100
LLSNPQFIVD
110
GATRTDICQG
120
ALGDCWLLAA
130
IASLTLNDTL
140
LHRVVPHGQS
150
FQNGYAGIFH
160
FQLWQFGEWV
170
DVVVDDLLPI
180
KDGKLVFVHS
190
AEGNEFWSAL
200
LEKAYAKVNG
210
SYEALSGGST
220
SEGFEDFTGG
230
VTEWYELRKA
240
PSDLYQIILK
250
ALERGSLLGC
260
SIDISSVLDM
270
EAITFKKLVK
280
GHAYSVTGAK
290
QVNYRGQVVS
300
LIRMRNPWGE
310
VEWTGAWSDS
320
SSEWNNVDPY
330
ERDQLRVKME
340
DGEFWMSFRD
350
FMREFTRLEI
360
CNLTPDALKS
370
RTIRKWNTTL
380
YEGTWRRGST
390
AGGCRNYPAT
400
FWVNPQFKIR
410
LDETDDPDDY
420
GDRESGCSFV
430
LALMQKHRRR
440
ERRFGRDMET
450
IGFAVYEVPP
460
ELVGQPAVHL
470
KRDFFLANAS
480
RARSEQFINL
490
REVSTRFRLP
500
PGEYVVVPST
510
FEPNKEGDFV
520
LRFFSEKSAG
530
TVELDDQIQA
540
NLPDEQVLSE
550
EEIDENFKAL
560
FRQLAGEDME
570
ISVKELRTIL
580
NRIISKHKDL
590
RTKGFSLESC
600
RSMVNLMDRD
610
GNGKLGLVEF
620
NILWNRIRNY
630
LSIFRKFDLD
640
KSGSMSAYEM
650
RMAIESAGFK
660
LNKKLYELII
670
TRYSEPDLAV
680
DFDNFVCCLV
690
RLETMFRFFK
700
TLDTDLDGVV
710
TFDLFKWLQL
TMFA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity |
| Molecular Function | GO:0008233 | peptidase activity |
| Biological Process | GO:0098989 | NMDA selective glutamate receptor signaling pathway |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0050790 | regulation of catalytic activity |
| Biological Process | GO:0016241 | regulation of macroautophagy |
| Biological Process | GO:0097264 | self proteolysis |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.