Search Results

Overview

Uniprot IDP07437
Protein NameTubulin beta chain
Gene NameTUBB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
58 YNEATGGKYVPRAIL

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

Protein Sequence

10 MREIVHIQAG 20 QCGNQIGAKF 30 WEVISDEHGI 40 DPTGTYHGDS 50 DLQLDRISVY 60 YNEATGGKYV 70 PRAILVDLEP 80 GTMDSVRSGP 90 FGQIFRPDNF 100 VFGQSGAGNN 110 WAKGHYTEGA 120 ELVDSVLDVV 130 RKEAESCDCL 140 QGFQLTHSLG 150 GGTGSGMGTL 160 LISKIREEYP 170 DRIMNTFSVV 180 PSPKVSDTVV 190 EPYNATLSVH 200 QLVENTDETY 210 CIDNEALYDI 220 CFRTLKLTTP 230 TYGDLNHLVS 240 ATMSGVTTCL 250 RFPGQLNADL 260 RKLAVNMVPF 270 PRLHFFMPGF 280 APLTSRGSQQ 290 YRALTVPELT 300 QQVFDAKNMM 310 AACDPRHGRY 320 LTVAAVFRGR 330 MSMKEVDEQM 340 LNVQNKNSSY 350 FVEWIPNNVK 360 TAVCDIPPRG 370 LKMAVTFIGN 380 STAIQELFKR 390 ISEQFTAMFR 400 RKAFLHWYTG 410 EGMDEMEFTE 420 AESNMNDLVS 430 EYQQYQDATA 440 EEEEDFGEEA EEEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0044297 cell body
Cellular Component GO:0097542 ciliary tip
Cellular Component GO:0005929 cilium
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0045171 intercellular bridge
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005641 nuclear envelope lumen
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0097229 sperm end piece
Cellular Component GO:0097228 sperm principal piece
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0032794 GTPase activating protein binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0042288 MHC class I protein binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0005198 structural molecule activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0051301 cell division
Biological Process GO:0030705 cytoskeleton-dependent intracellular transport
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0007017 microtubule-based process
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0042267 natural killer cell mediated cytotoxicity
Biological Process GO:0071895 odontoblast differentiation
Biological Process GO:0050807 regulation of synapse organization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.