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Overview

Uniprot IDP07451
Protein NameCarbonic anhydrase 3
Gene NameCA3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
131 NPKYNTFKEALKQRD
177 GKEAPFTKFDPSCLF

Function

Reversible hydration of carbon dioxide

Protein Sequence

10 MAKEWGYASH 20 NGPDHWHELF 30 PNAKGENQSP 40 VELHTKDIRH 50 DPSLQPWSVS 60 YDGGSAKTIL 70 NNGKTCRVVF 80 DDTYDRSMLR 90 GGPLPGPYRL 100 RQFHLHWGSS 110 DDHGSEHTVD 120 GVKYAAELHL 130 VHWNPKYNTF 140 KEALKQRDGI 150 AVIGIFLKIG 160 HENGEFQIFL 170 DALDKIKTKG 180 KEAPFTKFDP 190 SCLFPACRDY 200 WTYQGSFTTP 210 PCEECIVWLL 220 LKEPMTVSSD 230 QMAKLRSLLS 240 SAENEPPVPL 250 VSNWRPPQPI 260 NNRVVRASFK

Gene Ontology

Classification GO ID Description
Biological Process GO:0032869 cellular response to insulin stimulus
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0030017 sarcomere
Molecular Function GO:0004089 carbonate dehydratase activity
Molecular Function GO:0016791 phosphatase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0044320 cellular response to leptin stimulus
Biological Process GO:0097421 liver regeneration
Biological Process GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Biological Process GO:1903427 negative regulation of reactive oxygen species biosynthetic process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045471 response to ethanol
Biological Process GO:0033993 response to lipid
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0003009 skeletal muscle contraction

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.