Search Results
Overview
| Uniprot ID | P07477 |
|---|---|
| Protein Name | Serine protease 1 |
| Gene Name | PRSS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 225 | DGCAQKNKPGVYTKV |
Function
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates
Protein Sequence
10
MNPLLILTFV
20
AAALAAPFDD
30
DDKIVGGYNC
40
EENSVPYQVS
50
LNSGYHFCGG
60
SLINEQWVVS
70
AGHCYKSRIQ
80
VRLGEHNIEV
90
LEGNEQFINA
100
AKIIRHPQYD
110
RKTLNNDIML
120
IKLSSRAVIN
130
ARVSTISLPT
140
APPATGTKCL
150
ISGWGNTASS
160
GADYPDELQC
170
LDAPVLSQAK
180
CEASYPGKIT
190
SNMFCVGFLE
200
GGKDSCQGDS
210
GGPVVCNGQL
220
QGVVSWGDGC
230
AQKNKPGVYT
240
KVYNYVKWIK
NTIAANS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Biological Process | GO:0007586 | digestion |
| Biological Process | GO:0022617 | extracellular matrix disassembly |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.