Search Results
Overview
| Uniprot ID | P07585 |
|---|---|
| Protein Name | Decorin |
| Gene Name | DCN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | EIKDGDFKNLKNLHA |
| 119 | LVNNKISKVSPGAFT |
| 130 | GAFTPLVKLERLYLS |
| 138 | LERLYLSKNQLKELP |
| 142 | YLSKNQLKELPEKMP |
| 147 | QLKELPEKMPKTLQE |
| 150 | ELPEKMPKTLQELRA |
| 164 | AHENEITKVRKVTFN |
| 200 | NGAFQGMKKLSYIRI |
| 242 | RVDAASLKGLNNLAK |
| 280 | ELHLDNNKLTRVPGG |
| 321 | PPGHNTKKASYSGVS |
| 74 | CSDLGLDKVPKDLPP |
| 77 | LGLDKVPKDLPPDTT |
| 92 | LLDLQNNKITEIKDG |
| 97 | NNKITEIKDGDFKNL |
Function
May affect the rate of fibrils formation
Protein Sequence
10
MKATIILLLL
20
AQVSWAGPFQ
30
QRGLFDFMLE
40
DEASGIGPEV
50
PDDRDFEPSL
60
GPVCPFRCQC
70
HLRVVQCSDL
80
GLDKVPKDLP
90
PDTTLLDLQN
100
NKITEIKDGD
110
FKNLKNLHAL
120
ILVNNKISKV
130
SPGAFTPLVK
140
LERLYLSKNQ
150
LKELPEKMPK
160
TLQELRAHEN
170
EITKVRKVTF
180
NGLNQMIVIE
190
LGTNPLKSSG
200
IENGAFQGMK
210
KLSYIRIADT
220
NITSIPQGLP
230
PSLTELHLDG
240
NKISRVDAAS
250
LKGLNNLAKL
260
GLSFNSISAV
270
DNGSLANTPH
280
LRELHLDNNK
290
LTRVPGGLAE
300
HKYIQVVYLH
310
NNNISVVGSS
320
DFCPPGHNTK
330
KASYSGVSLF
340
SNPVQYWEIQ
350
PSTFRCVYVR
SAIQLGNYK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071953 | elastic fiber |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0140150 | gel phase of interstitial matrix |
| Cellular Component | GO:0005796 | Golgi lumen |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Cellular Component | GO:0001527 | microfibril |
| Molecular Function | GO:0050840 | extracellular matrix binding |
| Molecular Function | GO:0030021 | extracellular matrix structural constituent conferring compression resistance |
| Molecular Function | GO:0005539 | glycosaminoglycan binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0009887 | animal organ morphogenesis |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0010596 | negative regulation of endothelial cell migration |
| Biological Process | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:0016239 | positive regulation of macroautophagy |
| Biological Process | GO:0051901 | positive regulation of mitochondrial depolarization |
| Biological Process | GO:0090141 | positive regulation of mitochondrial fission |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.