Search Results
Overview
| Uniprot ID | P07602 |
|---|---|
| Protein Name | Prosaposin |
| Gene Name | PSAP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 414 | GFCEVCKKLVGYLDR |
Function
Saposins are specific low-molecular mass non-enzymatic glycoproteins that act as activator proteins for lysosomal sphingolipid-degrading enzymes, facilitating the hydrolysis of sphingolipids by extracting lipid substrates from membranes and presenting them to their respective enzymes. They are derived from a common precursor protein, prosaposin, which is proteolytically cleaved to yield four homologous proteins (saposin A, B, C, and D), each with distinct but partially overlapping lipid and enzyme specificities
Protein Sequence
10
MYALFLLASL
20
LGAALAGPVL
30
GLKECTRGSA
40
VWCQNVKTAS
50
DCGAVKHCLQ
60
TVWNKPTVKS
70
LPCDICKDVV
80
TAAGDMLKDN
90
ATEEEILVYL
100
EKTCDWLPKP
110
NMSASCKEIV
120
DSYLPVILDI
130
IKGEMSRPGE
140
VCSALNLCES
150
LQKHLAELNH
160
QKQLESNKIP
170
ELDMTEVVAP
180
FMANIPLLLY
190
PQDGPRSKPQ
200
PKDNGDVCQD
210
CIQMVTDIQT
220
AVRTNSTFVQ
230
ALVEHVKEEC
240
DRLGPGMADI
250
CKNYISQYSE
260
IAIQMMMHMQ
270
PKEICALVGF
280
CDEVKEMPMQ
290
TLVPAKVASK
300
NVIPALELVE
310
PIKKHEVPAK
320
SDVYCEVCEF
330
LVKEVTKLID
340
NNKTEKEILD
350
AFDKMCSKLP
360
KSLSEECQEV
370
VDTYGSSILS
380
ILLEEVSPEL
390
VCSMLHLCSG
400
TRLPALTVHV
410
TQPKDGGFCE
420
VCKKLVGYLD
430
RNLEKNSTKQ
440
EILAALEKGC
450
SFLPDPYQKQ
460
CDQFVAEYEP
470
VLIEILVEVM
480
DPSFVCLKIG
490
ACPSAHKPLL
500
GTEKCIWGPS
510
YWCQNTETAA
520
QCNAVEHCKR
HVWN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035577 | azurophil granule membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:1905573 | ganglioside GM1 binding |
| Molecular Function | GO:1905574 | ganglioside GM2 binding |
| Molecular Function | GO:1905575 | ganglioside GM3 binding |
| Molecular Function | GO:1905577 | ganglioside GP1c binding |
| Molecular Function | GO:1905576 | ganglioside GT1b binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Biological Process | GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| Biological Process | GO:0060742 | epithelial cell differentiation involved in prostate gland development |
| Biological Process | GO:1905572 | ganglioside GM1 transport to membrane |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0007041 | lysosomal transport |
| Biological Process | GO:0060736 | prostate gland growth |
| Biological Process | GO:0010506 | regulation of autophagy |
| Biological Process | GO:0019216 | regulation of lipid metabolic process |
| Biological Process | GO:0006665 | sphingolipid metabolic process |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.