Overview
| Uniprot ID | P07711 |
|---|
| Protein Name | Procathepsin L |
|---|
| Gene Name | CTSL |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 123 |
RSVDWREKGYVTPVK |
Function
Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells (By similarity). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (PubMed:10716919). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity)
Protein Sequence
10
MNPTLILAAF
20
CLGIASATLT
30
FDHSLEAQWT
40
KWKAMHNRLY
50
GMNEEGWRRA
60
VWEKNMKMIE
70
LHNQEYREGK
80
HSFTMAMNAF
90
GDMTSEEFRQ
100
VMNGFQNRKP
110
RKGKVFQEPL
120
FYEAPRSVDW
130
REKGYVTPVK
140
NQGQCGSCWA
150
FSATGALEGQ
160
MFRKTGRLIS
170
LSEQNLVDCS
180
GPQGNEGCNG
190
GLMDYAFQYV
200
QDNGGLDSEE
210
SYPYEATEES
220
CKYNPKYSVA
230
NDTGFVDIPK
240
QEKALMKAVA
250
TVGPISVAID
260
AGHESFLFYK
270
EGIYFEPDCS
280
SEDMDHGVLV
290
VGYGFESTES
300
DNNKYWLVKN
310
SWGEEWGMGG
320
YVKMAKDRRN
330
HCGIASAASY
PTV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0042583 |
chromaffin granule |
| Cellular Component |
GO:0071682 |
endocytic vesicle lumen |
| Cellular Component |
GO:0036021 |
endolysosome lumen |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0043202 |
lysosomal lumen |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0005771 |
multivesicular body |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005518 |
collagen binding |
| Molecular Function |
GO:0004197 |
cysteine-type endopeptidase activity |
| Molecular Function |
GO:0008234 |
cysteine-type peptidase activity |
| Molecular Function |
GO:0001968 |
fibronectin binding |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0043394 |
proteoglycan binding |
| Molecular Function |
GO:0097655 |
serpin family protein binding |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0019882 |
antigen processing and presentation |
| Biological Process |
GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
| Biological Process |
GO:0048002 |
antigen processing and presentation of peptide antigen |
| Biological Process |
GO:0043373 |
CD4-positive, alpha-beta T cell lineage commitment |
| Biological Process |
GO:0097067 |
cellular response to thyroid hormone stimulus |
| Biological Process |
GO:0030574 |
collagen catabolic process |
| Biological Process |
GO:0060309 |
elastin catabolic process |
| Biological Process |
GO:0034230 |
enkephalin processing |
| Biological Process |
GO:0039654 |
fusion of virus membrane with host endosome membrane |
| Biological Process |
GO:0019064 |
fusion of virus membrane with host plasma membrane |
| Biological Process |
GO:0071888 |
macrophage apoptotic process |
| Biological Process |
GO:0016540 |
protein autoprocessing |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:0051603 |
proteolysis involved in protein catabolic process |
| Biological Process |
GO:0019065 |
receptor-mediated endocytosis of virus by host cell |
| Biological Process |
GO:0046718 |
symbiont entry into host cell |
| Biological Process |
GO:0031638 |
zymogen activation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.