Search Results
Overview
| Uniprot ID | P07737 |
|---|---|
| Protein Name | Profilin-1 |
| Gene Name | PFN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | TFNVTVTKTDKTLVL |
| 108 | VTVTKTDKTLVLLMG |
| 116 | TLVLLMGKEGVHGGL |
| 126 | VHGGLINKKCYEMAS |
| 127 | HGGLINKKCYEMASH |
| 26 | DAAIVGYKDSPSVWA |
| 54 | EVGVLVGKDRSSFYV |
| 70 | GLTLGGQKCSVIRDS |
| 91 | FSMDLRTKSTGGAPT |
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0000774 | adenyl-nucleotide exchange factor activity |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0070064 | proline-rich region binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0098885 | modification of postsynaptic actin cytoskeleton |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0032232 | negative regulation of actin filament bundle assembly |
| Biological Process | GO:0051497 | negative regulation of stress fiber assembly |
| Biological Process | GO:0032233 | positive regulation of actin filament bundle assembly |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:1900029 | positive regulation of ruffle assembly |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
| Biological Process | GO:0060074 | synapse maturation |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.