Search Results
Overview
| Uniprot ID | P07741 |
|---|---|
| Protein Name | Adenine phosphoribosyltransferase |
| Gene Name | APRT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | KAELEIQKDALEPGQ |
| 34 | RDISPVLKDPASFRA |
Function
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Protein Sequence
10
MADSELQLVE
20
QRIRSFPDFP
30
TPGVVFRDIS
40
PVLKDPASFR
50
AAIGLLARHL
60
KATHGGRIDY
70
IAGLDSRGFL
80
FGPSLAQELG
90
LGCVLIRKRG
100
KLPGPTLWAS
110
YSLEYGKAEL
120
EIQKDALEPG
130
QRVVVVDDLL
140
ATGGTMNAAC
150
ELLGRLQAEV
160
LECVSLVELT
170
SLKGREKLAP
180
VPFFSLLQYE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Molecular Function | GO:0002055 | adenine binding |
| Molecular Function | GO:0003999 | adenine phosphoribosyltransferase activity |
| Molecular Function | GO:0016208 | AMP binding |
| Biological Process | GO:0006168 | adenine salvage |
| Biological Process | GO:0044209 | AMP salvage |
| Biological Process | GO:0032264 | IMP salvage |
| Biological Process | GO:0006166 | purine ribonucleoside salvage |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.