Search Results
Overview
| Uniprot ID | P07758 |
|---|---|
| Protein Name | Alpha-1-antitrypsin 1-1 |
| Gene Name | Serpina1a |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 181 | VINDFVEKGTQGKIA |
| 292 | LSKELISKFLLNRRR |
Function
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin
Protein Sequence
10
MTPSISWGLL
20
LLAGLCCLVP
30
SFLAEDVQET
40
DTSQKDQSPA
50
SHEIATNLGD
60
FAISLYRELV
70
HQSNTSNIFF
80
SPVSIATAFA
90
MLSLGSKGDT
100
HTQILEGLQF
110
NLTQTSEADI
120
HKSFQHLLQT
130
LNRPDSELQL
140
STGNGLFVNN
150
DLKLVEKFLE
160
EAKNHYQAEV
170
FSVNFAESEE
180
AKKVINDFVE
190
KGTQGKIAEA
200
VKKLDQDTVF
210
ALANYILFKG
220
KWKKPFDPEN
230
TEEAEFHVDE
240
STTVKVPMMT
250
LSGMLHVHHC
260
STLSSWVLLM
270
DYAGNATAVF
280
LLPDDGKMQH
290
LEQTLSKELI
300
SKFLLNRRRR
310
LAQIHFPRLS
320
ISGEYNLKTL
330
MSPLGITRIF
340
NNGADLSGIT
350
EENAPLKLSQ
360
AVHKAVLTID
370
ETGTEAAAVT
380
VLQMVPMSMP
390
PILRFDHPFL
400
FIIFEEHTQS
410
PIFLGKVVDP
THK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Molecular Function | GO:0004866 | endopeptidase inhibitor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:1900004 | negative regulation of serine-type endopeptidase activity |
| Biological Process | GO:0006487 | protein N-linked glycosylation |
| Biological Process | GO:0046687 | response to chromate |
| Biological Process | GO:0034097 | response to cytokine |
| Biological Process | GO:0010288 | response to lead ion |
| Biological Process | GO:0033986 | response to methanol |
| Biological Process | GO:0043434 | response to peptide hormone |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.