Search Results
Overview
| Uniprot ID | P07825 |
|---|---|
| Protein Name | Synaptophysin |
| Gene Name | Syp |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | AKGLSDVKMATDPEN |
| 17 | GGQFRVVKEPLGFVK |
| 186 | RQTGNTCKELRDPVT |
Function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)
Protein Sequence
10
MDVVNQLVAG
20
GQFRVVKEPL
30
GFVKVLQWVF
40
AIFAFATCGS
50
YTGELRLSVE
60
CANKTESALN
70
IEVEFEYPFR
80
LHQVYFDAPS
90
CVKGGTTKIF
100
LVGDYSSSAE
110
FFVTVAVFAF
120
LYSMGALATY
130
IFLQNKYREN
140
NKGPMMDFLA
150
TAVFAFMWLV
160
SSSAWAKGLS
170
DVKMATDPEN
180
IIKEMPMCRQ
190
TGNTCKELRD
200
PVTSGLNTSV
210
VFGFLNLVLW
220
VGNLWFVFKE
230
TGWAAPFMRA
240
PPGAPEKQPA
250
PGDAYGDAGY
260
GQGPGGYGPQ
270
DSYGPQGGYQ
280
PDYGQPASGG
290
GGYGPQGDYG
300
QQGYGQQGAP
TSFSNQM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045178 | basal part of cell |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0042169 | SH2 domain binding |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0051260 | protein homooligomerization |
| Biological Process | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:0048168 | regulation of neuronal synaptic plasticity |
| Biological Process | GO:2000474 | regulation of opioid receptor signaling pathway |
| Biological Process | GO:0048172 | regulation of short-term neuronal synaptic plasticity |
| Biological Process | GO:0010807 | regulation of synaptic vesicle priming |
| Biological Process | GO:1904645 | response to amyloid-beta |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0044309 | neuron spine |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0043195 | terminal bouton |
| Cellular Component | GO:0099096 | vestibular calyx terminal |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.