Search Results
Overview
| Uniprot ID | P07858 |
|---|---|
| Protein Name | Cathepsin B |
| Gene Name | CTSB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | PGYSPTYKQDKHYGY |
| 223 | SPTYKQDKHYGYNSY |
| 97 | WPQCPTIKEIRDQGS |
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105)
Protein Sequence
10
MWQLWASLCC
20
LLVLANARSR
30
PSFHPLSDEL
40
VNYVNKRNTT
50
WQAGHNFYNV
60
DMSYLKRLCG
70
TFLGGPKPPQ
80
RVMFTEDLKL
90
PASFDAREQW
100
PQCPTIKEIR
110
DQGSCGSCWA
120
FGAVEAISDR
130
ICIHTNAHVS
140
VEVSAEDLLT
150
CCGSMCGDGC
160
NGGYPAEAWN
170
FWTRKGLVSG
180
GLYESHVGCR
190
PYSIPPCEHH
200
VNGSRPPCTG
210
EGDTPKCSKI
220
CEPGYSPTYK
230
QDKHYGYNSY
240
SVSNSEKDIM
250
AEIYKNGPVE
260
GAFSVYSDFL
270
LYKSGVYQHV
280
TGEMMGGHAI
290
RILGWGVENG
300
TPYWLVANSW
310
NTDWGDNGFF
320
KILRGQDHCG
330
IESEVVAGIP
RTDQYWEKI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0036021 | endolysosome lumen |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:0008234 | cysteine-type peptidase activity |
| Molecular Function | GO:0008233 | peptidase activity |
| Molecular Function | GO:0043394 | proteoglycan binding |
| Biological Process | GO:0097067 | cellular response to thyroid hormone stimulus |
| Biological Process | GO:0030574 | collagen catabolic process |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0051603 | proteolysis involved in protein catabolic process |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0046718 | symbiont entry into host cell |
| Biological Process | GO:0006590 | thyroid hormone generation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.