Search Results
Overview
| Uniprot ID | P07895 |
|---|---|
| Protein Name | Superoxide dismutase [Mn], mitochondrial |
| Gene Name | Sod2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | PKGGGEPKGELLEAI |
| 122 | GELLEAIKRDFGSFE |
| 68 | NLNVTEEKYHEALAK |
| 75 | KYHEALAKGDVTTQV |
Function
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems
Protein Sequence
10
MLCRAACSAG
20
RRLGPAASTA
30
GSRHKHSLPD
40
LPYDYGALEP
50
HINAQIMQLH
60
HSKHHATYVN
70
NLNVTEEKYH
80
EALAKGDVTT
90
QVALQPALKF
100
NGGGHINHSI
110
FWTNLSPKGG
120
GEPKGELLEA
130
IKRDFGSFEK
140
FKEKLTAVSV
150
GVQGSGWGWL
160
GFNKEQGRLQ
170
IAACSNQDPL
180
QGTTGLIPLL
190
GIDVWEHAYY
200
LQYKNVRPDY
210
LKAIWNVINW
220
ENVSQRYIVC
KK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Molecular Function | GO:0019825 | oxygen binding |
| Molecular Function | GO:0004784 | superoxide dismutase activity |
| Biological Process | GO:0003069 | acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure |
| Biological Process | GO:0008637 | apoptotic mitochondrial changes |
| Biological Process | GO:0071361 | cellular response to ethanol |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0003032 | detection of oxygen |
| Biological Process | GO:0048773 | erythrophore differentiation |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0030097 | hemopoiesis |
| Biological Process | GO:0050665 | hydrogen peroxide biosynthetic process |
| Biological Process | GO:0042743 | hydrogen peroxide metabolic process |
| Biological Process | GO:0032364 | intracellular oxygen homeostasis |
| Biological Process | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| Biological Process | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0007626 | locomotory behavior |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0060586 | multicellular organismal-level iron ion homeostasis |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0045599 | negative regulation of fat cell differentiation |
| Biological Process | GO:0048147 | negative regulation of fibroblast proliferation |
| Biological Process | GO:1902631 | negative regulation of membrane hyperpolarization |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation |
| Biological Process | GO:0048666 | neuron development |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010729 | positive regulation of hydrogen peroxide biosynthetic process |
| Biological Process | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| Biological Process | GO:1905461 | positive regulation of vascular associated smooth muscle cell apoptotic process |
| Biological Process | GO:1905932 | positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching |
| Biological Process | GO:0009791 | post-embryonic development |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0050790 | regulation of catalytic activity |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001836 | release of cytochrome c from mitochondria |
| Biological Process | GO:0019430 | removal of superoxide radicals |
| Biological Process | GO:0022904 | respiratory electron transport chain |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0048678 | response to axon injury |
| Biological Process | GO:0046686 | response to cadmium ion |
| Biological Process | GO:0051602 | response to electrical stimulus |
| Biological Process | GO:0010332 | response to gamma radiation |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0055093 | response to hyperoxia |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0035902 | response to immobilization stress |
| Biological Process | GO:0035900 | response to isolation stress |
| Biological Process | GO:0033591 | response to L-ascorbic acid |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0071000 | response to magnetism |
| Biological Process | GO:0010042 | response to manganese ion |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0000302 | response to reactive oxygen species |
| Biological Process | GO:0010269 | response to selenium ion |
| Biological Process | GO:0034021 | response to silicon dioxide |
| Biological Process | GO:0000303 | response to superoxide |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0010043 | response to zinc ion |
| Biological Process | GO:0042554 | superoxide anion generation |
| Biological Process | GO:0006801 | superoxide metabolic process |
| Biological Process | GO:0042311 | vasodilation |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.