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Overview

Uniprot IDP07902
Protein NameGalactose-1-phosphate uridylyltransferase
Gene NameGALT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
371 VHYHLGQKDRETATI

Function

Plays an important role in galactose metabolism

Protein Sequence

10 MSRSGTDPQQ 20 RQQASEADAA 30 AATFRANDHQ 40 HIRYNPLQDE 50 WVLVSAHRMK 60 RPWQGQVEPQ 70 LLKTVPRHDP 80 LNPLCPGAIR 90 ANGEVNPQYD 100 STFLFDNDFP 110 ALQPDAPSPG 120 PSDHPLFQAK 130 SARGVCKVMC 140 FHPWSDVTLP 150 LMSVPEIRAV 160 VDAWASVTEE 170 LGAQYPWVQI 180 FENKGAMMGC 190 SNPHPHCQVW 200 ASSFLPDIAQ 210 REERSQQAYK 220 SQHGEPLLME 230 YSRQELLRKE 240 RLVLTSEHWL 250 VLVPFWATWP 260 YQTLLLPRRH 270 VRRLPELTPA 280 ERDDLASIMK 290 KLLTKYDNLF 300 ETSFPYSMGW 310 HGAPTGSEAG 320 ANWNHWQLHA 330 HYYPPLLRSA 340 TVRKFMVGYE 350 MLAQAQRDLT 360 PEQAAERLRA 370 LPEVHYHLGQ KDRETATIA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Molecular Function GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway
Biological Process GO:0006012 galactose metabolic process
Biological Process GO:0006011 UDP-alpha-D-glucose metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.