Search Results
Overview
| Uniprot ID | P07936 |
|---|---|
| Protein Name | Neuromodulin |
| Gene Name | Gap43 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | PKAEEPSKAGDAPSE |
| 114 | DAPSEEKKGEGDAAP |
| 125 | DAAPSEEKAGSAETE |
| 146 | TDNSPSSKAEDGPAK |
| 153 | KAEDGPAKEEPKQAD |
| 207 | AVDEAKPKESARQDE |
| 216 | SARQDEGKEDPEADQ |
| 26 | KIEQDGVKPEDKAHK |
| 30 | DGVKPEDKAHKAATK |
| 37 | KAHKAATKIQASFRG |
| 56 | KKLKDEKKGDAPAAE |
| 69 | AEAEAKEKDDAPVAD |
| 80 | PVADGVEKKEGDGSA |
| 81 | VADGVEKKEGDGSAT |
Function
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity)
Protein Sequence
10
MLCCMRRTKQ
20
VEKNDEDQKI
30
EQDGVKPEDK
40
AHKAATKIQA
50
SFRGHITRKK
60
LKDEKKGDAP
70
AAEAEAKEKD
80
DAPVADGVEK
90
KEGDGSATTD
100
AAPATSPKAE
110
EPSKAGDAPS
120
EEKKGEGDAA
130
PSEEKAGSAE
140
TESAAKATTD
150
NSPSSKAEDG
160
PAKEEPKQAD
170
VPAAVTDAAA
180
TTPAAEDAAK
190
AAQPPTETAE
200
SSQAEEEKEA
210
VDEAKPKESA
220
RQDEGKEDPE
ADQEHA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0031527 | filopodium membrane |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0032584 | growth cone membrane |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0035727 | lysophosphatidic acid binding |
| Molecular Function | GO:1901981 | phosphatidylinositol phosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Biological Process | GO:0016198 | axon choice point recognition |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0045165 | cell fate commitment |
| Biological Process | GO:0010001 | glial cell differentiation |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0051489 | regulation of filopodium assembly |
| Biological Process | GO:0040008 | regulation of growth |
| Biological Process | GO:0099150 | regulation of postsynaptic specialization assembly |
| Biological Process | GO:0010996 | response to auditory stimulus |
| Biological Process | GO:0042246 | tissue regeneration |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.