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Overview

Uniprot IDP07942
Protein NameLaminin subunit beta-1
Gene NameLAMB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1208 LEKAKALKISGVIGP
1661 NVEELKRKAAQNSGE
1680 EKVVYTVKQSAEDVK
1697 LDGELDEKYKKVENL
1700 ELDEKYKKVENLIAK
229 PRIQNLLKITNLRIK
239 NLRIKFVKLHTLGDN

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex (PubMed:23472759). It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons (By similarity). Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface (By similarity). As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway (By similarity)

Protein Sequence

10 MGLLQLLAFS 20 FLALCRARVR 30 AQEPEFSYGC 40 AEGSCYPATG 50 DLLIGRAQKL 60 SVTSTCGLHK 70 PEPYCIVSHL 80 QEDKKCFICN 90 SQDPYHETLN 100 PDSHLIENVV 110 TTFAPNRLKI 120 WWQSENGVEN 130 VTIQLDLEAE 140 FHFTHLIMTF 150 KTFRPAAMLI 160 ERSSDFGKTW 170 GVYRYFAYDC 180 EASFPGISTG 190 PMKKVDDIIC 200 DSRYSDIEPS 210 TEGEVIFRAL 220 DPAFKIEDPY 230 SPRIQNLLKI 240 TNLRIKFVKL 250 HTLGDNLLDS 260 RMEIREKYYY 270 AVYDMVVRGN 280 CFCYGHASEC 290 APVDGFNEEV 300 EGMVHGHCMC 310 RHNTKGLNCE 320 LCMDFYHDLP 330 WRPAEGRNSN 340 ACKKCNCNEH 350 SISCHFDMAV 360 YLATGNVSGG 370 VCDDCQHNTM 380 GRNCEQCKPF 390 YYQHPERDIR 400 DPNFCERCTC 410 DPAGSQNEGI 420 CDSYTDFSTG 430 LIAGQCRCKL 440 NVEGEHCDVC 450 KEGFYDLSSE 460 DPFGCKSCAC 470 NPLGTIPGGN 480 PCDSETGHCY 490 CKRLVTGQHC 500 DQCLPEHWGL 510 SNDLDGCRPC 520 DCDLGGALNN 530 SCFAESGQCS 540 CRPHMIGRQC 550 NEVEPGYYFA 560 TLDHYLYEAE 570 EANLGPGVSI 580 VERQYIQDRI 590 PSWTGAGFVR 600 VPEGAYLEFF 610 IDNIPYSMEY 620 DILIRYEPQL 630 PDHWEKAVIT 640 VQRPGRIPTS 650 SRCGNTIPDD 660 DNQVVSLSPG 670 SRYVVLPRPV 680 CFEKGTNYTV 690 RLELPQYTSS 700 DSDVESPYTL 710 IDSLVLMPYC 720 KSLDIFTVGG 730 SGDGVVTNSA 740 WETFQRYRCL 750 ENSRSVVKTP 760 MTDVCRNIIF 770 SISALLHQTG 780 LACECDPQGS 790 LSSVCDPNGG 800 QCQCRPNVVG 810 RTCNRCAPGT 820 FGFGPSGCKP 830 CECHLQGSVN 840 AFCNPVTGQC 850 HCFQGVYARQ 860 CDRCLPGHWG 870 FPSCQPCQCN 880 GHADDCDPVT 890 GECLNCQDYT 900 MGHNCERCLA 910 GYYGDPIIGS 920 GDHCRPCPCP 930 DGPDSGRQFA 940 RSCYQDPVTL 950 QLACVCDPGY 960 IGSRCDDCAS 970 GYFGNPSEVG 980 GSCQPCQCHN 990 NIDTTDPEAC 1000 DKETGRCLKC 1010 LYHTEGEHCQ 1020 FCRFGYYGDA 1030 LQQDCRKCVC 1040 NYLGTVQEHC 1050 NGSDCQCDKA 1060 TGQCLCLPNV 1070 IGQNCDRCAP 1080 NTWQLASGTG 1090 CDPCNCNAAH 1100 SFGPSCNEFT 1110 GQCQCMPGFG 1120 GRTCSECQEL 1130 FWGDPDVECR 1140 ACDCDPRGIE 1150 TPQCDQSTGQ 1160 CVCVEGVEGP 1170 RCDKCTRGYS 1180 GVFPDCTPCH 1190 QCFALWDVII 1200 AELTNRTHRF 1210 LEKAKALKIS 1220 GVIGPYRETV 1230 DSVERKVSEI 1240 KDILAQSPAA 1250 EPLKNIGNLF 1260 EEAEKLIKDV 1270 TEMMAQVEVK 1280 LSDTTSQSNS 1290 TAKELDSLQT 1300 EAESLDNTVK 1310 ELAEQLEFIK 1320 NSDIRGALDS 1330 ITKYFQMSLE 1340 AEERVNASTT 1350 EPNSTVEQSA 1360 LMRDRVEDVM 1370 MERESQFKEK 1380 QEEQARLLDE 1390 LAGKLQSLDL 1400 SAAAEMTCGT 1410 PPGASCSETE 1420 CGGPNCRTDE 1430 GERKCGGPGC 1440 GGLVTVAHNA 1450 WQKAMDLDQD 1460 VLSALAEVEQ 1470 LSKMVSEAKL 1480 RADEAKQSAE 1490 DILLKTNATK 1500 EKMDKSNEEL 1510 RNLIKQIRNF 1520 LTQDSADLDS 1530 IEAVANEVLK 1540 MEMPSTPQQL 1550 QNLTEDIRER 1560 VESLSQVEVI 1570 LQHSAADIAR 1580 AEMLLEEAKR 1590 ASKSATDVKV 1600 TADMVKEALE 1610 EAEKAQVAAE 1620 KAIKQADEDI 1630 QGTQNLLTSI 1640 ESETAASEET 1650 LFNASQRISE 1660 LERNVEELKR 1670 KAAQNSGEAE 1680 YIEKVVYTVK 1690 QSAEDVKKTL 1700 DGELDEKYKK 1710 VENLIAKKTE 1720 ESADARRKAE 1730 MLQNEAKTLL 1740 AQANSKLQLL 1750 KDLERKYEDN 1760 QRYLEDKAQE 1770 LARLEGEVRS 1780 LLKDISQKVA VYSTCL

Gene Ontology

Classification GO ID Description
Biological Process GO:0045785 positive regulation of cell adhesion
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005606 laminin-111 trimer
Cellular Component GO:0005607 laminin-211 trimer
Cellular Component GO:0043261 laminin-213 trimer
Cellular Component GO:0005611 laminin-311 trimer
Cellular Component GO:0043257 laminin-411 trimer
Cellular Component GO:0043259 laminin-511 trimer
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0043208 glycosphingolipid binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0048018 receptor ligand activity
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0007155 cell adhesion
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0031175 neuron projection development
Biological Process GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration
Biological Process GO:0042476 odontogenesis
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:2001046 positive regulation of integrin-mediated signaling pathway
Biological Process GO:0051149 positive regulation of muscle cell differentiation
Biological Process GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering
Biological Process GO:0110011 regulation of basement membrane organization
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0034446 substrate adhesion-dependent cell spreading

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.