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Overview

Uniprot IDP07943
Protein NameAldo-keto reductase family 1 member B1
Gene NameAkr1b1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
243 EIAAKYNKTTAQVLI

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates. It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose. This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls)

Protein Sequence

10 MASHLELNNG 20 TKMPTLGLGT 30 WKSPPGQVTE 40 AVKVAIDMGY 50 RHIDCAQVYQ 60 NEKEVGVALQ 70 EKLKEQVVKR 80 QDLFIVSKLW 90 CTFHDQSMVK 100 GACQKTLSDL 110 QLDYLDLYLI 120 HWPTGFKPGP 130 DYFPLDASGN 140 VIPSDTDFVD 150 TWTAMEQLVD 160 EGLVKAIGVS 170 NFNPLQIERI 180 LNKPGLKYKP 190 AVNQIECHPY 200 LTQEKLIEYC 210 HCKGIVVTAY 220 SPLGSPDRPW 230 AKPEDPSLLE 240 DPRIKEIAAK 250 YNKTTAQVLI 260 RFPIQRNLVV 270 IPKSVTPARI 280 AENFKVFDFE 290 LSNEDMATLL 300 SYNRNWRVCA 310 LMSCAKHKDY PFHAEV

Gene Ontology

Classification GO ID Description
Biological Process GO:0072205 metanephric collecting duct development
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0042629 mast cell granule
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0033010 paranodal junction
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0032838 plasma membrane bounded cell projection cytoplasm
Cellular Component GO:0043220 Schmidt-Lanterman incisure
Cellular Component GO:0097454 Schwann cell microvillus
Molecular Function GO:0004032 aldose reductase (NADPH) activity
Molecular Function GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity
Molecular Function GO:0047655 allyl-alcohol dehydrogenase activity
Molecular Function GO:0018505 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity
Molecular Function GO:0043795 glyceraldehyde oxidoreductase activity
Molecular Function GO:0047956 glycerol dehydrogenase (NADP+) activity
Molecular Function GO:0047939 L-glucuronate reductase activity
Molecular Function GO:0036130 prostaglandin H2 endoperoxidase reductase activity
Molecular Function GO:0001758 retinal dehydrogenase (NAD+) activity
Biological Process GO:0071475 cellular hyperosmotic salinity response
Biological Process GO:0097238 cellular response to methylglyoxal
Biological Process GO:1901653 cellular response to peptide
Biological Process GO:0044597 daunorubicin metabolic process
Biological Process GO:0044598 doxorubicin metabolic process
Biological Process GO:0002070 epithelial cell maturation
Biological Process GO:0046370 fructose biosynthetic process
Biological Process GO:0072061 inner medullary collecting duct development
Biological Process GO:0060135 maternal process involved in female pregnancy
Biological Process GO:0005996 monosaccharide metabolic process
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0042415 norepinephrine metabolic process
Biological Process GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0035809 regulation of urine volume
Biological Process GO:0003091 renal water homeostasis
Biological Process GO:0097066 response to thyroid hormone
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0006061 sorbitol biosynthetic process
Biological Process GO:0006060 sorbitol metabolic process
Biological Process GO:0031098 stress-activated protein kinase signaling cascade
Biological Process GO:0001894 tissue homeostasis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.