Search Results
Overview
| Uniprot ID | P07951 |
|---|---|
| Protein Name | Tropomyosin beta chain |
| Gene Name | TPM2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | RLATALQKLEEAEKA |
| 12 | KKKMQMLKLDKENAI |
| 128 | DESERGMKVIENRAM |
| 161 | IAEDSDRKYEEVARK |
| 168 | KYEEVARKLVILEGE |
Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization
Protein Sequence
10
MDAIKKKMQM
20
LKLDKENAID
30
RAEQAEADKK
40
QAEDRCKQLE
50
EEQQALQKKL
60
KGTEDEVEKY
70
SESVKEAQEK
80
LEQAEKKATD
90
AEADVASLNR
100
RIQLVEEELD
110
RAQERLATAL
120
QKLEEAEKAA
130
DESERGMKVI
140
ENRAMKDEEK
150
MELQEMQLKE
160
AKHIAEDSDR
170
KYEEVARKLV
180
ILEGELERSE
190
ERAEVAESKC
200
GDLEEELKIV
210
TNNLKSLEAQ
220
ADKYSTKEDK
230
YEEEIKLLEE
240
KLKEAETRAE
250
FAERSVAKLE
260
KTIDDLEDEV
270
YAQKMKYKAI
280
SEELDNALND
ITSL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005862 | muscle thin filament tropomyosin |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0008307 | structural constituent of muscle |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0043462 | regulation of ATP-dependent activity |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.