Search Results

Overview

Uniprot IDP07996
Protein NameThrombospondin-1
Gene NameTHBS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
110 TLLALERKDHSGQVF
262 RTNYIGHKTKDLQAI

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (PubMed:15014436, PubMed:18285447, PubMed:2430973, PubMed:6489349). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:14568985, PubMed:24511121, PubMed:29042481, PubMed:32679764). Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis (PubMed:14568985). Ligand for receptor CD47 (PubMed:19004835, PubMed:8550562). Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS (PubMed:29042481). Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36 (PubMed:10613822, PubMed:11134179, PubMed:1371676). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47 (PubMed:10613822, PubMed:11134179, PubMed:1371676, PubMed:32679764). Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner (PubMed:29042481). Ligand for immunoglobulin-like cell surface receptor SIRPA (PubMed:24511121). Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA (PubMed:24511121). Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging (PubMed:29042481, PubMed:32679764)

Protein Sequence

10 MGLAWGLGVL 20 FLMHVCGTNR 30 IPESGGDNSV 40 FDIFELTGAA 50 RKGSGRRLVK 60 GPDPSSPAFR 70 IEDANLIPPV 80 PDDKFQDLVD 90 AVRAEKGFLL 100 LASLRQMKKT 110 RGTLLALERK 120 DHSGQVFSVV 130 SNGKAGTLDL 140 SLTVQGKQHV 150 VSVEEALLAT 160 GQWKSITLFV 170 QEDRAQLYID 180 CEKMENAELD 190 VPIQSVFTRD 200 LASIARLRIA 210 KGGVNDNFQG 220 VLQNVRFVFG 230 TTPEDILRNK 240 GCSSSTSVLL 250 TLDNNVVNGS 260 SPAIRTNYIG 270 HKTKDLQAIC 280 GISCDELSSM 290 VLELRGLRTI 300 VTTLQDSIRK 310 VTEENKELAN 320 ELRRPPLCYH 330 NGVQYRNNEE 340 WTVDSCTECH 350 CQNSVTICKK 360 VSCPIMPCSN 370 ATVPDGECCP 380 RCWPSDSADD 390 GWSPWSEWTS 400 CSTSCGNGIQ 410 QRGRSCDSLN 420 NRCEGSSVQT 430 RTCHIQECDK 440 RFKQDGGWSH 450 WSPWSSCSVT 460 CGDGVITRIR 470 LCNSPSPQMN 480 GKPCEGEARE 490 TKACKKDACP 500 INGGWGPWSP 510 WDICSVTCGG 520 GVQKRSRLCN 530 NPTPQFGGKD 540 CVGDVTENQI 550 CNKQDCPIDG 560 CLSNPCFAGV 570 KCTSYPDGSW 580 KCGACPPGYS 590 GNGIQCTDVD 600 ECKEVPDACF 610 NHNGEHRCEN 620 TDPGYNCLPC 630 PPRFTGSQPF 640 GQGVEHATAN 650 KQVCKPRNPC 660 TDGTHDCNKN 670 AKCNYLGHYS 680 DPMYRCECKP 690 GYAGNGIICG 700 EDTDLDGWPN 710 ENLVCVANAT 720 YHCKKDNCPN 730 LPNSGQEDYD 740 KDGIGDACDD 750 DDDNDKIPDD 760 RDNCPFHYNP 770 AQYDYDRDDV 780 GDRCDNCPYN 790 HNPDQADTDN 800 NGEGDACAAD 810 IDGDGILNER 820 DNCQYVYNVD 830 QRDTDMDGVG 840 DQCDNCPLEH 850 NPDQLDSDSD 860 RIGDTCDNNQ 870 DIDEDGHQNN 880 LDNCPYVPNA 890 NQADHDKDGK 900 GDACDHDDDN 910 DGIPDDKDNC 920 RLVPNPDQKD 930 SDGDGRGDAC 940 KDDFDHDSVP 950 DIDDICPENV 960 DISETDFRRF 970 QMIPLDPKGT 980 SQNDPNWVVR 990 HQGKELVQTV 1000 NCDPGLAVGY 1010 DEFNAVDFSG 1020 TFFINTERDD 1030 DYAGFVFGYQ 1040 SSSRFYVVMW 1050 KQVTQSYWDT 1060 NPTRAQGYSG 1070 LSVKVVNSTT 1080 GPGEHLRNAL 1090 WHTGNTPGQV 1100 RTLWHDPRHI 1110 GWKDFTAYRW 1120 RLSHRPKTGF 1130 IRVVMYEGKK 1140 IMADSGPIYD 1150 KTYAGGRLGL 1160 FVFSQEMVFF 1170 SDLKYECRDP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Biological Process GO:0043032 positive regulation of macrophage activation
Biological Process GO:0010759 positive regulation of macrophage chemotaxis
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0042327 positive regulation of phosphorylation
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0032914 positive regulation of transforming growth factor beta1 production
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0009749 response to glucose
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0032026 response to magnesium ion
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0032570 response to progesterone
Biological Process GO:0033574 response to testosterone
Biological Process GO:0006986 response to unfolded protein
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0002040 sprouting angiogenesis
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005577 fibrinogen complex
Cellular Component GO:0031091 platelet alpha granule
Cellular Component GO:0031093 platelet alpha granule lumen
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0030141 secretory granule
Cellular Component GO:1990341 thrombospondin complex
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0070052 collagen V binding
Molecular Function GO:0004866 endopeptidase inhibitor activity
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0070051 fibrinogen binding
Molecular Function GO:0017134 fibroblast growth factor binding
Molecular Function GO:0001968 fibronectin binding
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0043236 laminin binding
Molecular Function GO:0030169 low-density lipoprotein particle binding
Molecular Function GO:0001786 phosphatidylserine binding
Molecular Function GO:0002020 protease binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0043394 proteoglycan binding
Molecular Function GO:0050431 transforming growth factor beta binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0048266 behavioral response to pain
Biological Process GO:0072378 blood coagulation, fibrin clot formation
Biological Process GO:0007155 cell adhesion
Biological Process GO:0016477 cell migration
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0002544 chronic inflammatory response
Biological Process GO:0043652 engulfment of apoptotic cell
Biological Process GO:0006955 immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0043537 negative regulation of blood vessel endothelial cell migration
Biological Process GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Biological Process GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0001953 negative regulation of cell-matrix adhesion
Biological Process GO:0002605 negative regulation of dendritic cell antigen processing and presentation
Biological Process GO:2001027 negative regulation of endothelial cell chemotaxis
Biological Process GO:0010596 negative regulation of endothelial cell migration
Biological Process GO:0001937 negative regulation of endothelial cell proliferation
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Biological Process GO:0051918 negative regulation of fibrinolysis
Biological Process GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
Biological Process GO:0051895 negative regulation of focal adhesion assembly
Biological Process GO:0032693 negative regulation of interleukin-10 production
Biological Process GO:0032695 negative regulation of interleukin-12 production
Biological Process GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
Biological Process GO:0010751 negative regulation of nitric oxide mediated signal transduction
Biological Process GO:0141151 negative regulation of nitric oxide-cGMP mediated signal transduction
Biological Process GO:0010757 negative regulation of plasminogen activation
Biological Process GO:0010754 negative regulation of receptor guanylyl cyclase signaling pathway
Biological Process GO:1903671 negative regulation of sprouting angiogenesis
Biological Process GO:0032720 negative regulation of tumor necrosis factor production
Biological Process GO:0038060 nitric oxide-cGMP-mediated signaling
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0050921 positive regulation of chemotaxis
Biological Process GO:2000353 positive regulation of endothelial cell apoptotic process
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0010763 positive regulation of fibroblast migration

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.