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Overview

Uniprot IDP08047
Protein NameTranscription factor Sp1
Gene NameSP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
19 TAVVKIEKGVGGNNG

Function

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity)

Protein Sequence

10 MSDQDHSMDE 20 MTAVVKIEKG 30 VGGNNGGNGN 40 GGGAFSQARS 50 SSTGSSSSTG 60 GGGQESQPSP 70 LALLAATCSR 80 IESPNENSNN 90 SQGPSQSGGT 100 GELDLTATQL 110 SQGANGWQII 120 SSSSGATPTS 130 KEQSGSSTNG 140 SNGSESSKNR 150 TVSGGQYVVA 160 AAPNLQNQQV 170 LTGLPGVMPN 180 IQYQVIPQFQ 190 TVDGQQLQFA 200 ATGAQVQQDG 210 SGQIQIIPGA 220 NQQIITNRGS 230 GGNIIAAMPN 240 LLQQAVPLQG 250 LANNVLSGQT 260 QYVTNVPVAL 270 NGNITLLPVN 280 SVSAATLTPS 290 SQAVTISSSG 300 SQESGSQPVT 310 SGTTISSASL 320 VSSQASSSSF 330 FTNANSYSTT 340 TTTSNMGIMN 350 FTTSGSSGTN 360 SQGQTPQRVS 370 GLQGSDALNI 380 QQNQTSGGSL 390 QAGQQKEGEQ 400 NQQTQQQQIL 410 IQPQLVQGGQ 420 ALQALQAAPL 430 SGQTFTTQAI 440 SQETLQNLQL 450 QAVPNSGPII 460 IRTPTVGPNG 470 QVSWQTLQLQ 480 NLQVQNPQAQ 490 TITLAPMQGV 500 SLGQTSSSNT 510 TLTPIASAAS 520 IPAGTVTVNA 530 AQLSSMPGLQ 540 TINLSALGTS 550 GIQVHPIQGL 560 PLAIANAPGD 570 HGAQLGLHGA 580 GGDGIHDDTA 590 GGEEGENSPD 600 AQPQAGRRTR 610 REACTCPYCK 620 DSEGRGSGDP 630 GKKKQHICHI 640 QGCGKVYGKT 650 SHLRAHLRWH 660 TGERPFMCTW 670 SYCGKRFTRS 680 DELQRHKRTH 690 TGEKKFACPE 700 CPKRFMRSDH 710 LSKHIKTHQN 720 KKGGPGVALS 730 VGTLPLDSGA 740 GSEGSGTATP 750 SALITTNMVA 760 MEAICPEGIA 770 RLANSGINVM 780 QVADLQSINI SGNGF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Biological Process GO:0034224 cellular response to zinc ion starvation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0043923 host-mediated activation of viral transcription
Biological Process GO:1902004 positive regulation of amyloid-beta formation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:2001235 positive regulation of apoptotic signaling pathway
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1904828 positive regulation of hydrogen sulfide biosynthetic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1905564 positive regulation of vascular endothelial cell proliferation
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0033194 response to hydroperoxide
Biological Process GO:0048511 rhythmic process
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032993 protein-DNA complex
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0043425 bHLH transcription factor binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0003690 double-stranded DNA binding
Molecular Function GO:0035035 histone acetyltransferase binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0001221 transcription coregulator binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0071391 cellular response to estrogen stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:1904568 cellular response to wortmannin

Reference

PMID: N/A