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Overview

Uniprot IDP08059
Protein NameGlucose-6-phosphate isomerase
Gene NameGPI
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
11 LTQNPQFKKLQTWYH
12 TQNPQFKKLQTWYHE
142 RVRSGEWKGYSGKSI
234 EWFLQSAKDPSAVAK
252 ALSTNTTKVKEFGID
34 RRLFEGDKDRFNHFS
366 SNGKYITKSGTRVDH
454 KELQAAGKSPEDFEK
461 KSPEDFEKLLPHKVF
466 FEKLLPHKVFEGNRP

Function

Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (By similarity). Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P (By similarity). In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility. Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons. Released by lectin-stimulated T-cells to induce immunoglobulin secretion (By similarity)

Protein Sequence

10 MAALTQNPQF 20 KKLQTWYHEH 30 RSDLNLRRLF 40 EGDKDRFNHF 50 SLNLNTNHGR 60 ILLDYSKNLV 70 TEAVMQMLVD 80 LAKSRGVEAA 90 RERMFNGEKI 100 NFTEDRAVLH 110 VALRNRSNTP 120 ILVDGKDVMP 130 EVNRVLEKMK 140 SFCKRVRSGE 150 WKGYSGKSIT 160 DVINIGIGGS 170 DLGPLMVTEA 180 LKPYSAEGPR 190 VWFVSNIDGT 200 HIAKTLATLN 210 PESSLFIIAS 220 KTFTTQETIT 230 NAETAKEWFL 240 QSAKDPSAVA 250 KHFVALSTNT 260 TKVKEFGIDP 270 QNMFEFWDWV 280 GGRYSLWSAI 290 GLSIALHVGF 300 DNFEQLLSGA 310 HWMDQHFRTT 320 PLEKNAPVLL 330 ALLGIWYINF 340 FGCETHAMLP 350 YDQYLHRFAA 360 YFQQGDMESN 370 GKYITKSGTR 380 VDHQTGPIVW 390 GEPGTNGQHA 400 FYQLIHQGTK 410 MIPCDFLIPV 420 QTQHPIRKGL 430 HHKILLANFL 440 AQTEALMKGK 450 STEEARKELQ 460 AAGKSPEDFE 470 KLLPHKVFEG 480 NRPTNSIVFT 490 KLTPFILGAL 500 IAMYEHKIFV 510 QGVIWDINSF 520 DQWGVELGKQ 530 LAKKIEPELD 540 GSSPVTSHDS 550 STNGLINFIK QEREARSQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0097367 carbohydrate derivative binding
Molecular Function GO:0005125 cytokine activity
Molecular Function GO:0047938 glucose-6-phosphate 1-epimerase activity
Molecular Function GO:0004347 glucose-6-phosphate isomerase activity
Molecular Function GO:0048029 monosaccharide binding
Molecular Function GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0051156 glucose 6-phosphate metabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:0002639 positive regulation of immunoglobulin production

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.