Search Results
Overview
| Uniprot ID | P08082 |
|---|---|
| Protein Name | Clathrin light chain B |
| Gene Name | Cltb |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | QELDAASKVTEQEWR |
| 134 | EWREKAKKDLEEWNQ |
| 184 | EAFVKESKEETPGTE |
| 204 | QLCDFNPKSSKQCKD |
| 223 | RSVLMSLKQTPLSR* |
Function
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles
Protein Sequence
10
MAEDFGFFSS
20
SESGAPEAAE
30
EDPAAAFLAQ
40
QESEIAGIEN
50
DSGFGAPAAS
60
QVASAQPGLA
70
SGGGSEDMGT
80
TVNGDVFQEA
90
NGPADGYAAI
100
AQADRLTQEP
110
ESIRKWREEQ
120
KKRLQELDAA
130
SKVTEQEWRE
140
KAKKDLEEWN
150
QRQSEQVEKN
160
KINNRIADKA
170
FYQQPDADTI
180
GYVASEEAFV
190
KESKEETPGT
200
EWEKVAQLCD
210
FNPKSSKQCK
220
DVSRLRSVLM
SLKQTPLSR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0060170 | ciliary membrane |
| Cellular Component | GO:0030118 | clathrin coat |
| Cellular Component | GO:0030132 | clathrin coat of coated pit |
| Cellular Component | GO:0030130 | clathrin coat of trans-Golgi network vesicle |
| Cellular Component | GO:0030125 | clathrin vesicle coat |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098835 | presynaptic endocytic zone membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0032050 | clathrin heavy chain binding |
| Molecular Function | GO:0005326 | neurotransmitter transmembrane transporter activity |
| Molecular Function | GO:0042277 | peptide binding |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0072583 | clathrin-dependent endocytosis |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:0006836 | neurotransmitter transport |
| Biological Process | GO:0016183 | synaptic vesicle coating |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.