Search Results

Overview

Uniprot ID	P08123
Protein Name	Collagen alpha-2(I) chain
Gene Name	COL1A2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1064	GPSGPAGKDGRTGHP
506	GPTGDPGKNGDKGHA
510	DPGKNGDKGHAGLAG
654	AAGIPGGKGEKGEPG
738	AAGQPGAKGERGAKG

Function

Type I collagen is a member of group I collagen (fibrillar forming collagen)

Protein Sequence

10 MLSFVDTRTL 20 LLLAVTLCLA 30 TCQSLQEETV 40 RKGPAGDRGP 50 RGERGPPGPP 60 GRDGEDGPTG 70 PPGPPGPPGP 80 PGLGGNFAAQ 90 YDGKGVGLGP 100 GPMGLMGPRG 110 PPGAAGAPGP 120 QGFQGPAGEP 130 GEPGQTGPAG 140 ARGPAGPPGK 150 AGEDGHPGKP 160 GRPGERGVVG 170 PQGARGFPGT 180 PGLPGFKGIR 190 GHNGLDGLKG 200 QPGAPGVKGE 210 PGAPGENGTP 220 GQTGARGLPG 230 ERGRVGAPGP 240 AGARGSDGSV 250 GPVGPAGPIG 260 SAGPPGFPGA 270 PGPKGEIGAV 280 GNAGPAGPAG 290 PRGEVGLPGL 300 SGPVGPPGNP 310 GANGLTGAKG 320 AAGLPGVAGA 330 PGLPGPRGIP 340 GPVGAAGATG 350 ARGLVGEPGP 360 AGSKGESGNK 370 GEPGSAGPQG 380 PPGPSGEEGK 390 RGPNGEAGSA 400 GPPGPPGLRG 410 SPGSRGLPGA 420 DGRAGVMGPP 430 GSRGASGPAG 440 VRGPNGDAGR 450 PGEPGLMGPR 460 GLPGSPGNIG 470 PAGKEGPVGL 480 PGIDGRPGPI 490 GPAGARGEPG 500 NIGFPGPKGP 510 TGDPGKNGDK 520 GHAGLAGARG 530 APGPDGNNGA 540 QGPPGPQGVQ 550 GGKGEQGPPG 560 PPGFQGLPGP 570 SGPAGEVGKP 580 GERGLHGEFG 590 LPGPAGPRGE 600 RGPPGESGAA 610 GPTGPIGSRG 620 PSGPPGPDGN 630 KGEPGVVGAV 640 GTAGPSGPSG 650 LPGERGAAGI 660 PGGKGEKGEP 670 GLRGEIGNPG 680 RDGARGAPGA 690 VGAPGPAGAT 700 GDRGEAGAAG 710 PAGPAGPRGS 720 PGERGEVGPA 730 GPNGFAGPAG 740 AAGQPGAKGE 750 RGAKGPKGEN 760 GVVGPTGPVG 770 AAGPAGPNGP 780 PGPAGSRGDG 790 GPPGMTGFPG 800 AAGRTGPPGP 810 SGISGPPGPP 820 GPAGKEGLRG 830 PRGDQGPVGR 840 TGEVGAVGPP 850 GFAGEKGPSG 860 EAGTAGPPGT 870 PGPQGLLGAP 880 GILGLPGSRG 890 ERGLPGVAGA 900 VGEPGPLGIA 910 GPPGARGPPG 920 AVGSPGVNGA 930 PGEAGRDGNP 940 GNDGPPGRDG 950 QPGHKGERGY 960 PGNIGPVGAA 970 GAPGPHGPVG 980 PAGKHGNRGE 990 TGPSGPVGPA 1000 GAVGPRGPSG 1010 PQGIRGDKGE 1020 PGEKGPRGLP 1030 GLKGHNGLQG 1040 LPGIAGHHGD 1050 QGAPGSVGPA 1060 GPRGPAGPSG 1070 PAGKDGRTGH 1080 PGTVGPAGIR 1090 GPQGHQGPAG 1100 PPGPPGPPGP 1110 PGVSGGGYDF 1120 GYDGDFYRAD 1130 QPRSAPSLRP 1140 KDYEVDATLK 1150 SLNNQIETLL 1160 TPEGSRKNPA 1170 RTCRDLRLSH 1180 PEWSSGYYWI 1190 DPNQGCTMDA 1200 IKVYCDFSTG 1210 ETCIRAQPEN 1220 IPAKNWYRSS 1230 KDKKHVWLGE 1240 TINAGSQFEY 1250 NVEGVTSKEM 1260 ATQLAFMRLL 1270 ANYASQNITY 1280 HCKNSIAYMD 1290 EETGNLKKAV 1300 ILQGSNDVEL 1310 VAEGNSRFTY 1320 TVLVDGCSKK 1330 TNEWGKTIIE 1340 YKTNKPSRLP 1350 FLDIAPLDIG 1360 GADQEFFVDI GPVCFK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005584	collagen type I trimer
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Molecular Function	GO:0005201	extracellular matrix structural constituent
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0048407	platelet-derived growth factor binding
Molecular Function	GO:0002020	protease binding
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Molecular Function	GO:0046332	SMAD binding
Biological Process	GO:0001568	blood vessel development
Biological Process	GO:0030199	collagen fibril organization
Biological Process	GO:0042476	odontogenesis
Biological Process	GO:0008217	regulation of blood pressure
Biological Process	GO:0007266	Rho protein signal transduction
Biological Process	GO:0001501	skeletal system development
Biological Process	GO:0043588	skin development
Biological Process	GO:0043589	skin morphogenesis
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.