Search Results

Overview

Uniprot IDP08133
Protein NameAnnexin A6
Gene NameANXA6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 YCDAKEIKDAISGIG
135 HQLVAAYKDAYERDL
224 EYLKTTGKPIEASIR
265 ERLFKAMKGLGTRDN
299 IFRTKYEKSLYSMIK
3 *****MAKPAQGAKY
306 KSLYSMIKNDTSGEY
314 NDTSGEYKKTLLKLS
354 AVARVELKGTVRPAN
370 FNPDADAKALRKAMK
377 KALRKAMKGLGTDED
40 MKGFGSDKEAILDII
406 QQIRQTFKSHFGRDL
418 RDLMTDLKSEISGDL
442 PPAHYDAKQLKKAME
446 YDAKQLKKAMEGAGT
478 RAINEAYKEDYHKSL
483 AYKEDYHKSLEDALS
579 YDVEHTIKKEMSGDV
580 DVEHTIKKEMSGDVR
598 VAIVQSVKNKPLFFA
600 IVQSVKNKPLFFADK
607 KPLFFADKLYKSMKG
613 DKLYKSMKGAGTDEK
620 KGAGTDEKTLTRIMV
63 QEVCQSYKSLYGKDL
644 IRREFIEKYDKSLHQ
647 EFIEKYDKSLHQAIE
68 SYKSLYGKDLIADLK
75 KDLIADLKYELTGKF
81 LKYELTGKFERLIVG
9 AKPAQGAKYRGSIHD

Function

May associate with CD21. May regulate the release of Ca(2+) from intracellular stores

Protein Sequence

10 MAKPAQGAKY 20 RGSIHDFPGF 30 DPNQDAEALY 40 TAMKGFGSDK 50 EAILDIITSR 60 SNRQRQEVCQ 70 SYKSLYGKDL 80 IADLKYELTG 90 KFERLIVGLM 100 RPPAYCDAKE 110 IKDAISGIGT 120 DEKCLIEILA 130 SRTNEQMHQL 140 VAAYKDAYER 150 DLEADIIGDT 160 SGHFQKMLVV 170 LLQGTREEDD 180 VVSEDLVQQD 190 VQDLYEAGEL 200 KWGTDEAQFI 210 YILGNRSKQH 220 LRLVFDEYLK 230 TTGKPIEASI 240 RGELSGDFEK 250 LMLAVVKCIR 260 STPEYFAERL 270 FKAMKGLGTR 280 DNTLIRIMVS 290 RSELDMLDIR 300 EIFRTKYEKS 310 LYSMIKNDTS 320 GEYKKTLLKL 330 SGGDDDAAGQ 340 FFPEAAQVAY 350 QMWELSAVAR 360 VELKGTVRPA 370 NDFNPDADAK 380 ALRKAMKGLG 390 TDEDTIIDII 400 THRSNVQRQQ 410 IRQTFKSHFG 420 RDLMTDLKSE 430 ISGDLARLIL 440 GLMMPPAHYD 450 AKQLKKAMEG 460 AGTDEKALIE 470 ILATRTNAEI 480 RAINEAYKED 490 YHKSLEDALS 500 SDTSGHFRRI 510 LISLATGHRE 520 EGGENLDQAR 530 EDAQVAAEIL 540 EIADTPSGDK 550 TSLETRFMTI 560 LCTRSYPHLR 570 RVFQEFIKMT 580 NYDVEHTIKK 590 EMSGDVRDAF 600 VAIVQSVKNK 610 PLFFADKLYK 620 SMKGAGTDEK 630 TLTRIMVSRS 640 EIDLLNIRRE 650 FIEKYDKSLH 660 QAIEGDTSGD 670 FLKALLALCG GED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0031902 late endosome membrane
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0012506 vesicle membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0048306 calcium-dependent protein binding
Molecular Function GO:0015485 cholesterol binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0015276 ligand-gated monoatomic ion channel activity
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0001786 phosphatidylserine binding
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0051560 mitochondrial calcium ion homeostasis
Biological Process GO:0034220 monoatomic ion transmembrane transport
Biological Process GO:0051283 negative regulation of sequestering of calcium ion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[9] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.