Search Results
Overview
| Uniprot ID | P08134 |
|---|---|
| Protein Name | Rho-related GTP-binding protein RhoC |
| Gene Name | RHOC |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 7 | *MAAIRKKLVIVGDG |
Function
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells
Protein Sequence
10
MAAIRKKLVI
20
VGDGACGKTC
30
LLIVFSKDQF
40
PEVYVPTVFE
50
NYIADIEVDG
60
KQVELALWDT
70
AGQEDYDRLR
80
PLSYPDTDVI
90
LMCFSIDSPD
100
SLENIPEKWT
110
PEVKHFCPNV
120
PIILVGNKKD
130
LRQDEHTRRE
140
LAKMKQEPVR
150
SEEGRDMANR
160
ISAFGYLECS
170
AKTKEGVREV
180
FEMATRAGLQ
190
VRKNKRRRGC
PIL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0044319 | wound healing, spreading of cells |
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032420 | stereocilium |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0043297 | apical junction assembly |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0060193 | positive regulation of lipase activity |
| Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:1902766 | skeletal muscle satellite cell migration |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.