Overview
| Uniprot ID | P08174 |
|---|
| Protein Name | Complement decay-accelerating factor |
|---|
| Gene Name | CD55 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 161 |
AVEFCKKKSCPNPGE |
Function
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829)
Protein Sequence
10
MTVARPSVPA
20
ALPLLGELPR
30
LLLLVLLCLP
40
AVWGDCGLPP
50
DVPNAQPALE
60
GRTSFPEDTV
70
ITYKCEESFV
80
KIPGEKDSVI
90
CLKGSQWSDI
100
EEFCNRSCEV
110
PTRLNSASLK
120
QPYITQNYFP
130
VGTVVEYECR
140
PGYRREPSLS
150
PKLTCLQNLK
160
WSTAVEFCKK
170
KSCPNPGEIR
180
NGQIDVPGGI
190
LFGATISFSC
200
NTGYKLFGST
210
SSFCLISGSS
220
VQWSDPLPEC
230
REIYCPAPPQ
240
IDNGIIQGER
250
DHYGYRQSVT
260
YACNKGFTMI
270
GEHSIYCTVN
280
NDEGEWSGPP
290
PECRGKSLTS
300
KVPPTVQKPT
310
TVNVPTTEVS
320
PTSQKTTTKT
330
TTPNAQATRS
340
TPVSRTTKHF
350
HETTPNKGSG
360
TTSGTTRLLS
370
GHTCFTLTGL
380
LGTLVTMGLL
T
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0033116 |
endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0101003 |
ficolin-1-rich granule membrane |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0030667 |
secretory granule membrane |
| Cellular Component |
GO:0098552 |
side of membrane |
| Cellular Component |
GO:0030133 |
transport vesicle |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0001618 |
virus receptor activity |
| Biological Process |
GO:0006958 |
complement activation, classical pathway |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0045916 |
negative regulation of complement activation |
| Biological Process |
GO:2000516 |
positive regulation of CD4-positive, alpha-beta T cell activation |
| Biological Process |
GO:2000563 |
positive regulation of CD4-positive, alpha-beta T cell proliferation |
| Biological Process |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
| Biological Process |
GO:0002726 |
positive regulation of T cell cytokine production |
| Biological Process |
GO:0030449 |
regulation of complement activation |
| Biological Process |
GO:1903659 |
regulation of complement-dependent cytotoxicity |
| Biological Process |
GO:0031664 |
regulation of lipopolysaccharide-mediated signaling pathway |
| Biological Process |
GO:0045730 |
respiratory burst |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.