Search Results
Overview
| Uniprot ID | P08183 |
|---|---|
| Protein Name | ATP-dependent translocase ABCB1 |
| Gene Name | ABCB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 826 | ANDAAQVKGAIGSRL |
Function
Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218)
Protein Sequence
10
MDLEGDRNGG
20
AKKKNFFKLN
30
NKSEKDKKEK
40
KPTVSVFSMF
50
RYSNWLDKLY
60
MVVGTLAAII
70
HGAGLPLMML
80
VFGEMTDIFA
90
NAGNLEDLMS
100
NITNRSDIND
110
TGFFMNLEED
120
MTRYAYYYSG
130
IGAGVLVAAY
140
IQVSFWCLAA
150
GRQIHKIRKQ
160
FFHAIMRQEI
170
GWFDVHDVGE
180
LNTRLTDDVS
190
KINEGIGDKI
200
GMFFQSMATF
210
FTGFIVGFTR
220
GWKLTLVILA
230
ISPVLGLSAA
240
VWAKILSSFT
250
DKELLAYAKA
260
GAVAEEVLAA
270
IRTVIAFGGQ
280
KKELERYNKN
290
LEEAKRIGIK
300
KAITANISIG
310
AAFLLIYASY
320
ALAFWYGTTL
330
VLSGEYSIGQ
340
VLTVFFSVLI
350
GAFSVGQASP
360
SIEAFANARG
370
AAYEIFKIID
380
NKPSIDSYSK
390
SGHKPDNIKG
400
NLEFRNVHFS
410
YPSRKEVKIL
420
KGLNLKVQSG
430
QTVALVGNSG
440
CGKSTTVQLM
450
QRLYDPTEGM
460
VSVDGQDIRT
470
INVRFLREII
480
GVVSQEPVLF
490
ATTIAENIRY
500
GRENVTMDEI
510
EKAVKEANAY
520
DFIMKLPHKF
530
DTLVGERGAQ
540
LSGGQKQRIA
550
IARALVRNPK
560
ILLLDEATSA
570
LDTESEAVVQ
580
VALDKARKGR
590
TTIVIAHRLS
600
TVRNADVIAG
610
FDDGVIVEKG
620
NHDELMKEKG
630
IYFKLVTMQT
640
AGNEVELENA
650
ADESKSEIDA
660
LEMSSNDSRS
670
SLIRKRSTRR
680
SVRGSQAQDR
690
KLSTKEALDE
700
SIPPVSFWRI
710
MKLNLTEWPY
720
FVVGVFCAII
730
NGGLQPAFAI
740
IFSKIIGVFT
750
RIDDPETKRQ
760
NSNLFSLLFL
770
ALGIISFITF
780
FLQGFTFGKA
790
GEILTKRLRY
800
MVFRSMLRQD
810
VSWFDDPKNT
820
TGALTTRLAN
830
DAAQVKGAIG
840
SRLAVITQNI
850
ANLGTGIIIS
860
FIYGWQLTLL
870
LLAIVPIIAI
880
AGVVEMKMLS
890
GQALKDKKEL
900
EGSGKIATEA
910
IENFRTVVSL
920
TQEQKFEHMY
930
AQSLQVPYRN
940
SLRKAHIFGI
950
TFSFTQAMMY
960
FSYAGCFRFG
970
AYLVAHKLMS
980
FEDVLLVFSA
990
VVFGAMAVGQ
1000
VSSFAPDYAK
1010
AKISAAHIIM
1020
IIEKTPLIDS
1030
YSTEGLMPNT
1040
LEGNVTFGEV
1050
VFNYPTRPDI
1060
PVLQGLSLEV
1070
KKGQTLALVG
1080
SSGCGKSTVV
1090
QLLERFYDPL
1100
AGKVLLDGKE
1110
IKRLNVQWLR
1120
AHLGIVSQEP
1130
ILFDCSIAEN
1140
IAYGDNSRVV
1150
SQEEIVRAAK
1160
EANIHAFIES
1170
LPNKYSTKVG
1180
DKGTQLSGGQ
1190
KQRIAIARAL
1200
VRQPHILLLD
1210
EATSALDTES
1220
EKVVQEALDK
1230
AREGRTCIVI
1240
AHRLSTIQNA
1250
DLIVVFQNGR
1260
VKEHGTHQQL
1270
LAQKGIYFSM
1280
VSVQAGTKRQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098591 | external side of apical plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008559 | ABC-type xenobiotic transporter activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0042626 | ATPase-coupled transmembrane transporter activity |
| Molecular Function | GO:0046943 | carboxylic acid transmembrane transporter activity |
| Molecular Function | GO:0099038 | ceramide floppase activity |
| Molecular Function | GO:0015562 | efflux transmembrane transporter activity |
| Molecular Function | GO:0140328 | floppase activity |
| Molecular Function | GO:0090554 | phosphatidylcholine floppase activity |
| Molecular Function | GO:0090555 | phosphatidylethanolamine flippase activity |
| Molecular Function | GO:0140341 | phosphatidylethanolamine floppase activity |
| Molecular Function | GO:0022857 | transmembrane transporter activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0042910 | xenobiotic transmembrane transporter activity |
| Biological Process | GO:1905039 | carboxylic acid transmembrane transport |
| Biological Process | GO:0099040 | ceramide translocation |
| Biological Process | GO:0140115 | export across plasma membrane |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0045332 | phospholipid translocation |
| Biological Process | GO:2001225 | regulation of chloride transport |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0072089 | stem cell proliferation |
| Biological Process | GO:0046865 | terpenoid transport |
| Biological Process | GO:0070633 | transepithelial transport |
| Biological Process | GO:0055085 | transmembrane transport |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
| Biological Process | GO:1990961 | xenobiotic detoxification by transmembrane export across the plasma membrane |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
| Biological Process | GO:1990962 | xenobiotic transport across blood-brain barrier |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.