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Overview

Uniprot IDP08185
Protein NameCorticosteroid-binding globulin
Gene NameSERPINA6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
60 HLVALSPKKNIFISP

Function

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species

Protein Sequence

10 MPLLLYTCLL 20 WLPTSGLWTV 30 QAMDPNAAYV 40 NMSNHHRGLA 50 SANVDFAFSL 60 YKHLVALSPK 70 KNIFISPVSI 80 SMALAMLSLG 90 TCGHTRAQLL 100 QGLGFNLTER 110 SETEIHQGFQ 120 HLHQLFAKSD 130 TSLEMTMGNA 140 LFLDGSLELL 150 ESFSADIKHY 160 YESEVLAMNF 170 QDWATASRQI 180 NSYVKNKTQG 190 KIVDLFSGLD 200 SPAILVLVNY 210 IFFKGTWTQP 220 FDLASTREEN 230 FYVDETTVVK 240 VPMMLQSSTI 250 SYLHDSELPC 260 QLVQMNYVGN 270 GTVFFILPDK 280 GKMNTVIAAL 290 SRDTINRWSA 300 GLTSSQVDLY 310 IPKVTISGVY 320 DLGDVLEEMG 330 IADLFTNQAN 340 FSRITQDAQL 350 KSSKVVHKAV 360 LQLNEEGVDT 370 AGSTGVTLNL 380 TSKPIILRFN 390 QPFIIMIFDH 400 FTWSSLFLAR VMNPV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0140104 molecular carrier activity
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Molecular Function GO:0005496 steroid binding
Biological Process GO:0006704 glucocorticoid biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.