Search Results
Overview
| Uniprot ID | P08228 |
|---|---|
| Protein Name | Superoxide dismutase [Cu-Zn] |
| Gene Name | Sod1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | MKAVCVLKGDGPVQG |
| 137 | GGNEESTKTGNAGSR |
| 92 | LGNVTAGKDGVANVS |
Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides
Protein Sequence
10
MAMKAVCVLK
20
GDGPVQGTIH
30
FEQKASGEPV
40
VLSGQITGLT
50
EGQHGFHVHQ
60
YGDNTQGCTS
70
AGPHFNPHSK
80
KHGGPADEER
90
HVGDLGNVTA
100
GKDGVANVSI
110
EDRVISLSGE
120
HSIIGRTMVV
130
HEKQDDLGKG
140
GNEESTKTGN
150
AGSRLACGVI
GIAQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904115 | axon cytoplasm |
| Biological Process | GO:0032930 | positive regulation of superoxide anion generation |
| Biological Process | GO:0072593 | reactive oxygen species metabolic process |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
| Biological Process | GO:0040014 | regulation of multicellular organism growth |
| Biological Process | GO:0060087 | relaxation of vascular associated smooth muscle |
| Biological Process | GO:0019430 | removal of superoxide radicals |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0097332 | response to antipsychotic drug |
| Biological Process | GO:0048678 | response to axon injury |
| Biological Process | GO:0034465 | response to carbon monoxide |
| Biological Process | GO:0046688 | response to copper ion |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0000302 | response to reactive oxygen species |
| Biological Process | GO:0000303 | response to superoxide |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0001895 | retina homeostasis |
| Biological Process | GO:0008090 | retrograde axonal transport |
| Biological Process | GO:0007605 | sensory perception of sound |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0042554 | superoxide anion generation |
| Biological Process | GO:0006801 | superoxide metabolic process |
| Biological Process | GO:0019226 | transmission of nerve impulse |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0031045 | dense core granule |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005777 | peroxisome |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0030141 | secretory granule |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0030346 | protein phosphatase 2B binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0004784 | superoxide dismutase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0099610 | action potential initiation |
| Biological Process | GO:0008089 | anterograde axonal transport |
| Biological Process | GO:0060088 | auditory receptor cell stereocilium organization |
| Biological Process | GO:0071318 | cellular response to ATP |
| Biological Process | GO:0071276 | cellular response to cadmium ion |
| Biological Process | GO:0035865 | cellular response to potassium ion |
| Biological Process | GO:0008340 | determination of adult lifespan |
| Biological Process | GO:0007566 | embryo implantation |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0060047 | heart contraction |
| Biological Process | GO:0050665 | hydrogen peroxide biosynthetic process |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0007626 | locomotory behavior |
| Biological Process | GO:0046716 | muscle cell cellular homeostasis |
| Biological Process | GO:0002262 | myeloid cell homeostasis |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0060052 | neurofilament cytoskeleton organization |
| Biological Process | GO:0019228 | neuronal action potential |
| Biological Process | GO:0001541 | ovarian follicle development |
| Biological Process | GO:0032287 | peripheral nervous system myelin maintenance |
| Biological Process | GO:0043085 | positive regulation of catalytic activity |
| Biological Process | GO:0001819 | positive regulation of cytokine production |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:1902177 | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.
[2] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.