Search Results
Overview
| Uniprot ID | P08236 |
|---|---|
| Protein Name | Beta-glucuronidase |
| Gene Name | GUSB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 576 | YHLGLDQKRRKYVVG |
Function
Plays an important role in the degradation of dermatan and keratan sulfates
Protein Sequence
10
MARGSAVAWA
20
ALGPLLWGCA
30
LGLQGGMLYP
40
QESPSRECKE
50
LDGLWSFRAD
60
FSDNRRRGFE
70
EQWYRRPLWE
80
SGPTVDMPVP
90
SSFNDISQDW
100
RLRHFVGWVW
110
YEREVILPER
120
WTQDLRTRVV
130
LRIGSAHSYA
140
IVWVNGVDTL
150
EHEGGYLPFE
160
ADISNLVQVG
170
PLPSRLRITI
180
AINNTLTPTT
190
LPPGTIQYLT
200
DTSKYPKGYF
210
VQNTYFDFFN
220
YAGLQRSVLL
230
YTTPTTYIDD
240
ITVTTSVEQD
250
SGLVNYQISV
260
KGSNLFKLEV
270
RLLDAENKVV
280
ANGTGTQGQL
290
KVPGVSLWWP
300
YLMHERPAYL
310
YSLEVQLTAQ
320
TSLGPVSDFY
330
TLPVGIRTVA
340
VTKSQFLING
350
KPFYFHGVNK
360
HEDADIRGKG
370
FDWPLLVKDF
380
NLLRWLGANA
390
FRTSHYPYAE
400
EVMQMCDRYG
410
IVVIDECPGV
420
GLALPQFFNN
430
VSLHHHMQVM
440
EEVVRRDKNH
450
PAVVMWSVAN
460
EPASHLESAG
470
YYLKMVIAHT
480
KSLDPSRPVT
490
FVSNSNYAAD
500
KGAPYVDVIC
510
LNSYYSWYHD
520
YGHLELIQLQ
530
LATQFENWYK
540
KYQKPIIQSE
550
YGAETIAGFH
560
QDPPLMFTEE
570
YQKSLLEQYH
580
LGLDQKRRKY
590
VVGELIWNFA
600
DFMTEQSPTR
610
VLGNKKGIFT
620
RQRQPKSAAF
630
LLRERYWKIA
640
NETRYPHSVA
650
KSQCLENSLF
T
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0004566 | beta-glucuronidase activity |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:0030207 | chondroitin sulfate proteoglycan catabolic process |
| Biological Process | GO:0006027 | glycosaminoglycan catabolic process |
| Biological Process | GO:0030200 | heparan sulfate proteoglycan catabolic process |
| Biological Process | GO:0030214 | hyaluronan catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.