Search Results

Overview

Uniprot ID	P08240
Protein Name	Signal recognition particle receptor subunit alpha
Gene Name	SRPRA
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
138	RAPTTMKKFEDSEKA
174	SKKKGAKKEGSDGPL
220	KREEFIQKHGRGMEK
233	EKSNKSTKSDAPKEK

Function

Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957)

Protein Sequence

10 MLDFFTIFSK 20 GGLVLWCFQG 30 VSDSCTGPVN 40 ALIRSVLLQE 50 RGGNNSFTHE 60 ALTLKYKLDN 70 QFELVFVVGF 80 QKILTLTYVD 90 KLIDDVHRLF 100 RDKYRTEIQQ 110 QSALSLLNGT 120 FDFQNDFLRL 130 LREAEESSKI 140 RAPTTMKKFE 150 DSEKAKKPVR 160 SMIETRGEKP 170 KEKAKNSKKK 180 GAKKEGSDGP 190 LATSKPVPAE 200 KSGLPVGPEN 210 GVELSKEELI 220 RRKREEFIQK 230 HGRGMEKSNK 240 STKSDAPKEK 250 GKKAPRVWEL 260 GGCANKEVLD 270 YSTPTTNGTP 280 EAALSEDINL 290 IRGTGSGGQL 300 QDLDCSSSDD 310 EGAAQNSTKP 320 SATKGTLGGM 330 FGMLKGLVGS 340 KSLSREDMES 350 VLDKMRDHLI 360 AKNVAADIAV 370 QLCESVANKL 380 EGKVMGTFST 390 VTSTVKQALQ 400 ESLVQILQPQ 410 RRVDMLRDIM 420 DAQRRQRPYV 430 VTFCGVNGVG 440 KSTNLAKISF 450 WLLENGFSVL 460 IAACDTFRAG 470 AVEQLRTHTR 480 RLSALHPPEK 490 HGGRTMVQLF 500 EKGYGKDAAG 510 IAMEAIAFAR 520 NQGFDVVLVD 530 TAGRMQDNAP 540 LMTALAKLIT 550 VNTPDLVLFV 560 GEALVGNEAV 570 DQLVKFNRAL 580 ADHSMAQTPR 590 LIDGIVLTKF 600 DTIDDKVGAA 610 ISMTYITSKP 620 IVFVGTGQTY 630 CDLRSLNAKA VVAALMKA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005785	signal recognition particle receptor complex
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0005047	signal recognition particle binding
Biological Process	GO:0006613	cotranslational protein targeting to membrane
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0045047	protein targeting to ER
Biological Process	GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.