Search Results
Overview
| Uniprot ID | P08247 |
|---|---|
| Protein Name | Synaptophysin |
| Gene Name | SYP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 23 | GGQFRVVKEPLGFVK |
Function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)
Protein Sequence
10
MLLLADMDVV
20
NQLVAGGQFR
30
VVKEPLGFVK
40
VLQWVFAIFA
50
FATCGSYSGE
60
LQLSVDCANK
70
TESDLSIEVE
80
FEYPFRLHQV
90
YFDAPTCRGG
100
TTKVFLVGDY
110
SSSAEFFVTV
120
AVFAFLYSMG
130
ALATYIFLQN
140
KYRENNKGPM
150
LDFLATAVFA
160
FMWLVSSSAW
170
AKGLSDVKMA
180
TDPENIIKEM
190
PVCRQTGNTC
200
KELRDPVTSG
210
LNTSVVFGFL
220
NLVLWVGNLW
230
FVFKETGWAA
240
PFLRAPPGAP
250
EKQPAPGDAY
260
GDAGYGQGPG
270
GYGPQDSYGP
280
QGGYQPDYGQ
290
PAGSGGSGYG
300
PQGDYGQQGY
310
GPQGAPTSFS
NQM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042169 | SH2 domain binding |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:0048168 | regulation of neuronal synaptic plasticity |
| Biological Process | GO:2000474 | regulation of opioid receptor signaling pathway |
| Biological Process | GO:0048172 | regulation of short-term neuronal synaptic plasticity |
| Biological Process | GO:0010807 | regulation of synaptic vesicle priming |
| Biological Process | GO:0016188 | synaptic vesicle maturation |
| Biological Process | GO:0048499 | synaptic vesicle membrane organization |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.