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Overview

Uniprot IDP08263
Protein NameGlutathione S-transferase A1
Gene NameGSTA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
120 PPEEKDAKLALIKEK
125 DAKLALIKEKIKNRY
138 RYFPAFEKVLKSHGQ
141 PAFEKVLKSHGQDYL
152 QDYLVGNKLSRADIH
195 ISNLPTVKKFLQPGS
196 SNLPTVKKFLQPGSP
205 LQPGSPRKPPMDEKS
211 RKPPMDEKSLEEARK
36 EFEEKFIKSAEDLDK
43 KSAEDLDKLRNDGYL
6 **MAEKPKLHYFNAR
84 SKYNLYGKDIKERAL

Function

Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487)

Protein Sequence

10 MAEKPKLHYF 20 NARGRMESTR 30 WLLAAAGVEF 40 EEKFIKSAED 50 LDKLRNDGYL 60 MFQQVPMVEI 70 DGMKLVQTRA 80 ILNYIASKYN 90 LYGKDIKERA 100 LIDMYIEGIA 110 DLGEMILLLP 120 VCPPEEKDAK 130 LALIKEKIKN 140 RYFPAFEKVL 150 KSHGQDYLVG 160 NKLSRADIHL 170 VELLYYVEEL 180 DSSLISSFPL 190 LKALKTRISN 200 LPTVKKFLQP 210 GSPRKPPMDE 220 KSLEEARKIF RF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0005504 fatty acid binding
Molecular Function GO:0004602 glutathione peroxidase activity
Molecular Function GO:0004364 glutathione transferase activity
Molecular Function GO:0140104 molecular carrier activity
Molecular Function GO:0004769 steroid Delta-isomerase activity
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:1901687 glutathione derivative biosynthetic process
Biological Process GO:0006749 glutathione metabolic process
Biological Process GO:0042167 heme catabolic process
Biological Process GO:0043651 linoleic acid metabolic process
Biological Process GO:0006693 prostaglandin metabolic process
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.