Search Results

Overview

Uniprot IDP08319
Protein NameAll-trans-retinol dehydrogenase [NAD(+)] ADH4
Gene NameADH4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 APLCRKCKFCLSPLT
11 KGKVIKCKAAIAWEA
115 PLTNLCGKISNLKSP
120 CGKISNLKSPASDQQ
132 DQQLMEDKTSRFTCK
20 AIAWEAGKPLCIEEV
234 GIDINSEKFVKAKAL
239 SEKFVKAKALGATDC
254 LNPRDLHKPIQEVII
329 GTFFGGWKSVDSIPK
33 EVEVAPPKAHEVRIQ
336 KSVDSIPKLVTDYKN
342 PKLVTDYKNKKFNLD
345 VTDYKNKKFNLDALV
372 FDLMNQGKSVRTILI
86 GPGVTNVKPGDKVIP

Function

Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444)

Protein Sequence

10 MGTKGKVIKC 20 KAAIAWEAGK 30 PLCIEEVEVA 40 PPKAHEVRIQ 50 IIATSLCHTD 60 ATVIDSKFEG 70 LAFPVIVGHE 80 AAGIVESIGP 90 GVTNVKPGDK 100 VIPLYAPLCR 110 KCKFCLSPLT 120 NLCGKISNLK 130 SPASDQQLME 140 DKTSRFTCKG 150 KPVYHFFGTS 160 TFSQYTVVSD 170 INLAKIDDDA 180 NLERVCLLGC 190 GFSTGYGAAI 200 NNAKVTPGST 210 CAVFGLGGVG 220 LSAVMGCKAA 230 GASRIIGIDI 240 NSEKFVKAKA 250 LGATDCLNPR 260 DLHKPIQEVI 270 IELTKGGVDF 280 ALDCAGGSET 290 MKAALDCTTA 300 GWGSCTFIGV 310 AAGSKGLTIF 320 PEELIIGRTI 330 NGTFFGGWKS 340 VDSIPKLVTD 350 YKNKKFNLDA 360 LVTHTLPFDK 370 ISEAFDLMNQ 380 GKSVRTILIF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0004022 alcohol dehydrogenase (NAD+) activity
Molecular Function GO:0004032 aldose reductase (NADPH) activity
Molecular Function GO:0005503 all-trans retinal binding
Molecular Function GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
Molecular Function GO:0018479 benzaldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0003960 quinone reductase (NADPH) activity
Molecular Function GO:0019841 retinol binding
Molecular Function GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0046164 alcohol catabolic process
Biological Process GO:0006066 alcohol metabolic process
Biological Process GO:0006081 aldehyde metabolic process
Biological Process GO:0010430 fatty acid omega-oxidation
Biological Process GO:0046294 formaldehyde catabolic process
Biological Process GO:1901661 quinone metabolic process
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0042572 retinol metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.