Search Results

Overview

Uniprot IDP08413
Protein NameCalcium/calmodulin-dependent protein kinase type II subunit beta
Gene NameCamk2b
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
147 ENLLLASKCKGAAVK
268 ITAHEALKHPWVCQR
301 FNARRKLKGAILTTM
33 SVVRRCVKLCTGHEY
348 AKSLLNKKADGVKPQ
360 KPQTNSTKNSSAITS
43 TGHEYAAKIINTKKL
57 LSARDHQKLEREARI
69 ARICRLLKHSNIVRL

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:12873385, PubMed:15312654). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise (PubMed:17272343). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-134' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (By similarity)

Protein Sequence

10 MATTVTCTRF 20 TDEYQLYEDI 30 GKGAFSVVRR 40 CVKLCTGHEY 50 AAKIINTKKL 60 SARDHQKLER 70 EARICRLLKH 80 SNIVRLHDSI 90 SEEGFHYLVF 100 DLVTGGELFE 110 DIVAREYYSE 120 ADASHCIQQI 130 LEAVLHCHQM 140 GVVHRDLKPE 150 NLLLASKCKG 160 AAVKLADFGL 170 AIEVQGDQQA 180 WFGFAGTPGY 190 LSPEVLRKEA 200 YGKPVDIWAC 210 GVILYILLVG 220 YPPFWDEDQH 230 KLYQQIKAGA 240 YDFPSPEWDT 250 VTPEAKNLIN 260 QMLTINPAKR 270 ITAHEALKHP 280 WVCQRSTVAS 290 MMHRQETVEC 300 LKKFNARRKL 310 KGAILTTMLA 320 TRNFSVGRQT 330 TAPATMSTAA 340 SGTTMGLVEQ 350 AKSLLNKKAD 360 GVKPQTNSTK 370 NSSAITSPKG 380 SLPPAALEPQ 390 TTVIHNPVDG 400 IKESSDSTNT 410 TIEDEDAKAR 420 KQEIIKTTEQ 430 LIEAVNNGDF 440 EAYAKICDPG 450 LTSFEPEALG 460 NLVEGMDFHR 470 FYFENLLAKN 480 SKPIHTTILN 490 PHVHVIGEDA 500 ACIAYIRLTQ 510 YIDGQGRPRT 520 SQSEETRVWH 530 RPDGKWQNVH 540 FHCSGAPVAP LQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005954 calcium- and calmodulin-dependent protein kinase complex
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043204 perikaryon
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Cellular Component GO:0051233 spindle midzone
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004683 calcium/calmodulin-dependent protein kinase activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0043274 phospholipase binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0098973 structural constituent of postsynaptic actin cytoskeleton
Biological Process GO:0060466 activation of meiosis involved in egg activation
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0030154 cell differentiation
Biological Process GO:0048858 cell projection morphogenesis
Biological Process GO:1905375 cellular response to homocysteine
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0110088 hippocampal neuron apoptotic process
Biological Process GO:0002030 inhibitory G protein-coupled receptor phosphorylation
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0007399 nervous system development
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:2001235 positive regulation of apoptotic signaling pathway
Biological Process GO:0061003 positive regulation of dendritic spine morphogenesis
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0010518 positive regulation of phospholipase activity
Biological Process GO:0090129 positive regulation of synapse maturation
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0048169 regulation of long-term neuronal synaptic plasticity
Biological Process GO:2001222 regulation of neuron migration
Biological Process GO:0048168 regulation of neuronal synaptic plasticity
Biological Process GO:1903076 regulation of protein localization to plasma membrane
Biological Process GO:0090128 regulation of synapse maturation
Biological Process GO:0032222 regulation of synaptic transmission, cholinergic
Biological Process GO:0046686 response to cadmium ion
Biological Process GO:1990911 response to psychosocial stress

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.