Search Results
Overview
| Uniprot ID | P08567 |
|---|---|
| Protein Name | Pleckstrin |
| Gene Name | PLEK |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 64 | SPCQDFGKRMFVFKI |
Function
Major protein kinase C substrate of platelets
Protein Sequence
10
MEPKRIREGY
20
LVKKGSVFNT
30
WKPMWVVLLE
40
DGIEFYKKKS
50
DNSPKGMIPL
60
KGSTLTSPCQ
70
DFGKRMFVFK
80
ITTTKQQDHF
90
FQAAFLEERD
100
AWVRDIKKAI
110
KCIEGGQKFA
120
RKSTRRSIRL
130
PETIDLGALY
140
LSMKDTEKGI
150
KELNLEKDKK
160
IFNHCFTGNC
170
VIDWLVSNQS
180
VRNRQEGLMI
190
ASSLLNEGYL
200
QPAGDMSKSA
210
VDGTAENPFL
220
DNPDAFYYFP
230
DSGFFCEENS
240
SDDDVILKEE
250
FRGVIIKQGC
260
LLKQGHRRKN
270
WKVRKFILRE
280
DPAYLHYYDP
290
AGAEDPLGAI
300
HLRGCVVTSV
310
ESNSNGRKSE
320
EENLFEIITA
330
DEVHYFLQAA
340
TPKERTEWIR
350
AIQMASRTGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032587 | ruffle membrane |
| Molecular Function | GO:0019211 | phosphatase activator activity |
| Molecular Function | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0030866 | cortical actin cytoskeleton organization |
| Biological Process | GO:0002244 | hematopoietic progenitor cell differentiation |
| Biological Process | GO:0043647 | inositol phosphate metabolic process |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0050849 | negative regulation of calcium-mediated signaling |
| Biological Process | GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway |
| Biological Process | GO:0010920 | negative regulation of inositol phosphate biosynthetic process |
| Biological Process | GO:0070495 | negative regulation of thrombin-activated receptor signaling pathway |
| Biological Process | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0030845 | phospholipase C-inhibiting G protein-coupled receptor signaling pathway |
| Biological Process | GO:0070527 | platelet aggregation |
| Biological Process | GO:0002576 | platelet degranulation |
| Biological Process | GO:0032233 | positive regulation of actin filament bundle assembly |
| Biological Process | GO:0030836 | positive regulation of actin filament depolymerization |
| Biological Process | GO:0033625 | positive regulation of integrin activation |
| Biological Process | GO:0010572 | positive regulation of platelet activation |
| Biological Process | GO:0070560 | protein secretion by platelet |
| Biological Process | GO:0060305 | regulation of cell diameter |
| Biological Process | GO:0031529 | ruffle organization |
| Biological Process | GO:0070493 | thrombin-activated receptor signaling pathway |
| Biological Process | GO:0006904 | vesicle docking involved in exocytosis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.