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Overview

Uniprot IDP08571
Protein NameMonocyte differentiation antigen CD14
Gene NameCD14
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
87 RQYADTVKALRVRRL

Function

Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:22265692, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187)

Protein Sequence

10 MERASCLLLL 20 LLPLVHVSAT 30 TPEPCELDDE 40 DFRCVCNFSE 50 PQPDWSEAFQ 60 CVSAVEVEIH 70 AGGLNLEPFL 80 KRVDADADPR 90 QYADTVKALR 100 VRRLTVGAAQ 110 VPAQLLVGAL 120 RVLAYSRLKE 130 LTLEDLKITG 140 TMPPLPLEAT 150 GLALSSLRLR 160 NVSWATGRSW 170 LAELQQWLKP 180 GLKVLSIAQA 190 HSPAFSCEQV 200 RAFPALTSLD 210 LSDNPGLGER 220 GLMAALCPHK 230 FPAIQNLALR 240 NTGMETPTGV 250 CAALAAAGVQ 260 PHSLDLSHNS 270 LRATVNPSAP 280 RCMWSSALNS 290 LNLSFAGLEQ 300 VPKGLPAKLR 310 VLDLSCNRLN 320 RAPQPDELPE 330 VDNLTLDGNP 340 FLVPGTALPH 350 EGSMNSGVVP 360 ACARSTLSVG 370 VSGTLVLLQG ARGFA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0046696 lipopolysaccharide receptor complex
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030667 secretory granule membrane
Molecular Function GO:0001530 lipopolysaccharide binding
Molecular Function GO:0001875 lipopolysaccharide immune receptor activity
Molecular Function GO:0070891 lipoteichoic acid binding
Molecular Function GO:0140104 molecular carrier activity
Molecular Function GO:0001847 opsonin receptor activity
Molecular Function GO:0016019 peptidoglycan immune receptor activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0002752 cell surface pattern recognition receptor signaling pathway
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0071726 cellular response to diacyl bacterial lipopeptide
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0071223 cellular response to lipoteichoic acid
Biological Process GO:0071219 cellular response to molecule of bacterial origin
Biological Process GO:0071727 cellular response to triacyl bacterial lipopeptide
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0006909 phagocytosis
Biological Process GO:0001819 positive regulation of cytokine production
Biological Process GO:0045807 positive regulation of endocytosis
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
Biological Process GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0032481 positive regulation of type I interferon production
Biological Process GO:0032729 positive regulation of type II interferon production
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0034142 toll-like receptor 4 signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.