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Overview

Uniprot IDP08574
Protein NameCytochrome c1, heme protein, mitochondrial
Gene NameCYC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
170 EMFMRPGKLFDYFPK
310 VYTIKRHKWSVLKSR
318 WSVLKSRKLAYRPPK

Function

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c

Protein Sequence

10 MAAAAASLRG 20 VVLGPRGAGL 30 PGARARGLLC 40 SARPGQLPLR 50 TPQAVALSSK 60 SGLSRGRKVM 70 LSALGMLAAG 80 GAGLAMALHS 90 AVSASDLELH 100 PPSYPWSHRG 110 LLSSLDHTSI 120 RRGFQVYKQV 130 CASCHSMDFV 140 AYRHLVGVCY 150 TEDEAKELAA 160 EVEVQDGPNE 170 DGEMFMRPGK 180 LFDYFPKPYP 190 NSEAARAANN 200 GALPPDLSYI 210 VRARHGGEDY 220 VFSLLTGYCE 230 PPTGVSLREG 240 LYFNPYFPGQ 250 AIAMAPPIYT 260 DVLEFDDGTP 270 ATMSQIAKDV 280 CTFLRWASEP 290 EHDHRKRMGL 300 KMLMMMALLV 310 PLVYTIKRHK 320 WSVLKSRKLA YRPPK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Biological Process GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
Biological Process GO:0033762 response to glucagon
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0045275 respiratory chain complex III
Molecular Function GO:0020037 heme binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0008121 quinol-cytochrome-c reductase activity
Biological Process GO:0045333 cellular respiration

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.