Search Results
Overview
| Uniprot ID | P08575 |
|---|---|
| Protein Name | Receptor-type tyrosine-protein phosphatase C |
| Gene Name | PTPRC |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 969 | IGNQEENKSKNRNSN |
Function
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity
Protein Sequence
10
MTMYLWLKLL
20
AFGFAFLDTE
30
VFVTGQSPTP
40
SPTGLTTAKM
50
PSVPLSSDPL
60
PTHTTAFSPA
70
STFERENDFS
80
ETTTSLSPDN
90
TSTQVSPDSL
100
DNASAFNTTG
110
VSSVQTPHLP
120
THADSQTPSA
130
GTDTQTFSGS
140
AANAKLNPTP
150
GSNAISDVPG
160
ERSTASTFPT
170
DPVSPLTTTL
180
SLAHHSSAAL
190
PARTSNTTIT
200
ANTSDAYLNA
210
SETTTLSPSG
220
SAVISTTTIA
230
TTPSKPTCDE
240
KYANITVDYL
250
YNKETKLFTA
260
KLNVNENVEC
270
GNNTCTNNEV
280
HNLTECKNAS
290
VSISHNSCTA
300
PDKTLILDVP
310
PGVEKFQLHD
320
CTQVEKADTT
330
ICLKWKNIET
340
FTCDTQNITY
350
RFQCGNMIFD
360
NKEIKLENLE
370
PEHEYKCDSE
380
ILYNNHKFTN
390
ASKIIKTDFG
400
SPGEPQIIFC
410
RSEAAHQGVI
420
TWNPPQRSFH
430
NFTLCYIKET
440
EKDCLNLDKN
450
LIKYDLQNLK
460
PYTKYVLSLH
470
AYIIAKVQRN
480
GSAAMCHFTT
490
KSAPPSQVWN
500
MTVSMTSDNS
510
MHVKCRPPRD
520
RNGPHERYHL
530
EVEAGNTLVR
540
NESHKNCDFR
550
VKDLQYSTDY
560
TFKAYFHNGD
570
YPGEPFILHH
580
STSYNSKALI
590
AFLAFLIIVT
600
SIALLVVLYK
610
IYDLHKKRSC
620
NLDEQQELVE
630
RDDEKQLMNV
640
EPIHADILLE
650
TYKRKIADEG
660
RLFLAEFQSI
670
PRVFSKFPIK
680
EARKPFNQNK
690
NRYVDILPYD
700
YNRVELSEIN
710
GDAGSNYINA
720
SYIDGFKEPR
730
KYIAAQGPRD
740
ETVDDFWRMI
750
WEQKATVIVM
760
VTRCEEGNRN
770
KCAEYWPSME
780
EGTRAFGDVV
790
VKINQHKRCP
800
DYIIQKLNIV
810
NKKEKATGRE
820
VTHIQFTSWP
830
DHGVPEDPHL
840
LLKLRRRVNA
850
FSNFFSGPIV
860
VHCSAGVGRT
870
GTYIGIDAML
880
EGLEAENKVD
890
VYGYVVKLRR
900
QRCLMVQVEA
910
QYILIHQALV
920
EYNQFGETEV
930
NLSELHPYLH
940
NMKKRDPPSE
950
PSPLEAEFQR
960
LPSYRSWRTQ
970
HIGNQEENKS
980
KNRNSNVIPY
990
DYNRVPLKHE
1000
LEMSKESEHD
1010
SDESSDDDSD
1020
SEEPSKYINA
1030
SFIMSYWKPE
1040
VMIAAQGPLK
1050
ETIGDFWQMI
1060
FQRKVKVIVM
1070
LTELKHGDQE
1080
ICAQYWGEGK
1090
QTYGDIEVDL
1100
KDTDKSSTYT
1110
LRVFELRHSK
1120
RKDSRTVYQY
1130
QYTNWSVEQL
1140
PAEPKELISM
1150
IQVVKQKLPQ
1160
KNSSEGNKHH
1170
KSTPLLIHCR
1180
DGSQQTGIFC
1190
ALLNLLESAE
1200
TEEVVDIFQV
1210
VKALRKARPG
1220
MVSTFEQYQF
1230
LYDVIASTYP
1240
AQNGQVKKNN
1250
HQEDKIEFDN
1260
EVDKVKQDAN
1270
CVNPLGAPEK
1280
LPEAKEQAEG
1290
SEPTSGTEGP
1300
EHSVNGPASP
ALNQGS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:2000648 | positive regulation of stem cell proliferation |
| Cellular Component | GO:0032059 | bleb |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0098857 | membrane microdomain |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030667 | secretory granule membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0030506 | ankyrin binding |
| Molecular Function | GO:0043395 | heparan sulfate proteoglycan binding |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030292 | protein tyrosine kinase inhibitor activity |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0030507 | spectrin binding |
| Molecular Function | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity |
| Biological Process | GO:0030183 | B cell differentiation |
| Biological Process | GO:0042100 | B cell proliferation |
| Biological Process | GO:0050853 | B cell receptor signaling pathway |
| Biological Process | GO:0048539 | bone marrow development |
| Biological Process | GO:0044770 | cell cycle phase transition |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0051607 | defense response to virus |
| Biological Process | GO:0016311 | dephosphorylation |
| Biological Process | GO:1904155 | DN2 thymocyte differentiation |
| Biological Process | GO:0002244 | hematopoietic progenitor cell differentiation |
| Biological Process | GO:0001779 | natural killer cell differentiation |
| Biological Process | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration |
| Biological Process | GO:0001960 | negative regulation of cytokine-mediated signaling pathway |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0032703 | negative regulation of interleukin-2 production |
| Biological Process | GO:1902215 | negative regulation of interleukin-4-mediated signaling pathway |
| Biological Process | GO:1903979 | negative regulation of microglial cell activation |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:0046426 | negative regulation of receptor signaling pathway via JAK-STAT |
| Biological Process | GO:0001915 | negative regulation of T cell mediated cytotoxicity |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0044855 | plasma membrane raft distribution |
| Biological Process | GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway |
| Biological Process | GO:0030890 | positive regulation of B cell proliferation |
| Biological Process | GO:0050850 | positive regulation of calcium-mediated signaling |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0060369 | positive regulation of Fc receptor mediated stimulatory signaling pathway |
| Biological Process | GO:2000473 | positive regulation of hematopoietic stem cell migration |
| Biological Process | GO:0002639 | positive regulation of immunoglobulin production |
| Biological Process | GO:0032743 | positive regulation of interleukin-2 production |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:0045860 | positive regulation of protein kinase activity |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0032677 | regulation of interleukin-8 production |
| Biological Process | GO:0050764 | regulation of phagocytosis |
| Biological Process | GO:0050856 | regulation of T cell receptor signaling pathway |
| Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol |
| Biological Process | GO:1904044 | response to aldosterone |
| Biological Process | GO:0010332 | response to gamma radiation |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0048864 | stem cell development |
| Biological Process | GO:0042110 | T cell activation |
| Biological Process | GO:0030217 | T cell differentiation |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.