Search Results

Overview

Uniprot ID	P08581
Protein Name	Hepatocyte growth factor receptor
Gene Name	MET
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1132	LTEGIIMKDFSHPNV

Function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity)

Protein Sequence

10 MKAPAVLAPG 20 ILVLLFTLVQ 30 RSNGECKEAL 40 AKSEMNVNMK 50 YQLPNFTAET 60 PIQNVILHEH 70 HIFLGATNYI 80 YVLNEEDLQK 90 VAEYKTGPVL 100 EHPDCFPCQD 110 CSSKANLSGG 120 VWKDNINMAL 130 VVDTYYDDQL 140 ISCGSVNRGT 150 CQRHVFPHNH 160 TADIQSEVHC 170 IFSPQIEEPS 180 QCPDCVVSAL 190 GAKVLSSVKD 200 RFINFFVGNT 210 INSSYFPDHP 220 LHSISVRRLK 230 ETKDGFMFLT 240 DQSYIDVLPE 250 FRDSYPIKYV 260 HAFESNNFIY 270 FLTVQRETLD 280 AQTFHTRIIR 290 FCSINSGLHS 300 YMEMPLECIL 310 TEKRKKRSTK 320 KEVFNILQAA 330 YVSKPGAQLA 340 RQIGASLNDD 350 ILFGVFAQSK 360 PDSAEPMDRS 370 AMCAFPIKYV 380 NDFFNKIVNK 390 NNVRCLQHFY 400 GPNHEHCFNR 410 TLLRNSSGCE 420 ARRDEYRTEF 430 TTALQRVDLF 440 MGQFSEVLLT 450 SISTFIKGDL 460 TIANLGTSEG 470 RFMQVVVSRS 480 GPSTPHVNFL 490 LDSHPVSPEV 500 IVEHTLNQNG 510 YTLVITGKKI 520 TKIPLNGLGC 530 RHFQSCSQCL 540 SAPPFVQCGW 550 CHDKCVRSEE 560 CLSGTWTQQI 570 CLPAIYKVFP 580 NSAPLEGGTR 590 LTICGWDFGF 600 RRNNKFDLKK 610 TRVLLGNESC 620 TLTLSESTMN 630 TLKCTVGPAM 640 NKHFNMSIII 650 SNGHGTTQYS 660 TFSYVDPVIT 670 SISPKYGPMA 680 GGTLLTLTGN 690 YLNSGNSRHI 700 SIGGKTCTLK 710 SVSNSILECY 720 TPAQTISTEF 730 AVKLKIDLAN 740 RETSIFSYRE 750 DPIVYEIHPT 760 KSFISGGSTI 770 TGVGKNLNSV 780 SVPRMVINVH 790 EAGRNFTVAC 800 QHRSNSEIIC 810 CTTPSLQQLN 820 LQLPLKTKAF 830 FMLDGILSKY 840 FDLIYVHNPV 850 FKPFEKPVMI 860 SMGNENVLEI 870 KGNDIDPEAV 880 KGEVLKVGNK 890 SCENIHLHSE 900 AVLCTVPNDL 910 LKLNSELNIE 920 WKQAISSTVL 930 GKVIVQPDQN 940 FTGLIAGVVS 950 ISTALLLLLG 960 FFLWLKKRKQ 970 IKDLGSELVR 980 YDARVHTPHL 990 DRLVSARSVS 1000 PTTEMVSNES 1010 VDYRATFPED 1020 QFPNSSQNGS 1030 CRQVQYPLTD 1040 MSPILTSGDS 1050 DISSPLLQNT 1060 VHIDLSALNP 1070 ELVQAVQHVV 1080 IGPSSLIVHF 1090 NEVIGRGHFG 1100 CVYHGTLLDN 1110 DGKKIHCAVK 1120 SLNRITDIGE 1130 VSQFLTEGII 1140 MKDFSHPNVL 1150 SLLGICLRSE 1160 GSPLVVLPYM 1170 KHGDLRNFIR 1180 NETHNPTVKD 1190 LIGFGLQVAK 1200 GMKYLASKKF 1210 VHRDLAARNC 1220 MLDEKFTVKV 1230 ADFGLARDMY 1240 DKEYYSVHNK 1250 TGAKLPVKWM 1260 ALESLQTQKF 1270 TTKSDVWSFG 1280 VLLWELMTRG 1290 APPYPDVNTF 1300 DITVYLLQGR 1310 RLLQPEYCPD 1320 PLYEVMLKCW 1330 HPKAEMRPSF 1340 SELVSRISAI 1350 FSTFIGEHYV 1360 HVNATYVNVK 1370 CVAPYPSLLS 1380 SEDNADDEVD 1390 TRPASFWETS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009925	basal plasma membrane
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098794	postsynapse
Cellular Component	GO:0043235	receptor complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0005008	hepatocyte growth factor receptor activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0140677	molecular function activator activity
Molecular Function	GO:0019903	protein phosphatase binding
Molecular Function	GO:0004713	protein tyrosine kinase activity
Molecular Function	GO:0017154	semaphorin receptor activity
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube
Biological Process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway
Biological Process	GO:0007166	cell surface receptor signaling pathway
Biological Process	GO:0001886	endothelial cell morphogenesis
Biological Process	GO:0060079	excitatory postsynaptic potential
Biological Process	GO:0048012	hepatocyte growth factor receptor signaling pathway
Biological Process	GO:0001889	liver development
Biological Process	GO:0010507	negative regulation of autophagy
Biological Process	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
Biological Process	GO:0030182	neuron differentiation
Biological Process	GO:0031016	pancreas development
Biological Process	GO:0050918	positive chemotaxis
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0071526	semaphorin-plexin signaling pathway

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.