Search Results

Overview

Uniprot IDP08603
Protein NameComplement factor H
Gene NameCFH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1066 IVSRQMSKYPSGERV
1222 RTTCWDGKLEYPTCA
1230 LEYPTCAKR******
200 SDDGFWSKEKPKCVE
236 ENERFQYKCNMGYEY
410 GRKFVQGKSIDVACH
68 NVIMVCRKGEWVALN
754 IDKLKKCKSSNLIIL
766 IILEEHLKNKKEFDH
769 EEHLKNKKEFDHNSN
784 IRYRCRGKEGWIHTV

Function

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed:21285368, PubMed:21317894, PubMed:25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed:19503104, PubMed:21317894, PubMed:26700768). As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed:18252712, PubMed:23332154, PubMed:28671664). In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed (PubMed:20008295, PubMed:9558116)

Protein Sequence

10 MRLLAKIICL 20 MLWAICVAED 30 CNELPPRRNT 40 EILTGSWSDQ 50 TYPEGTQAIY 60 KCRPGYRSLG 70 NVIMVCRKGE 80 WVALNPLRKC 90 QKRPCGHPGD 100 TPFGTFTLTG 110 GNVFEYGVKA 120 VYTCNEGYQL 130 LGEINYRECD 140 TDGWTNDIPI 150 CEVVKCLPVT 160 APENGKIVSS 170 AMEPDREYHF 180 GQAVRFVCNS 190 GYKIEGDEEM 200 HCSDDGFWSK 210 EKPKCVEISC 220 KSPDVINGSP 230 ISQKIIYKEN 240 ERFQYKCNMG 250 YEYSERGDAV 260 CTESGWRPLP 270 SCEEKSCDNP 280 YIPNGDYSPL 290 RIKHRTGDEI 300 TYQCRNGFYP 310 ATRGNTAKCT 320 STGWIPAPRC 330 TLKPCDYPDI 340 KHGGLYHENM 350 RRPYFPVAVG 360 KYYSYYCDEH 370 FETPSGSYWD 380 HIHCTQDGWS 390 PAVPCLRKCY 400 FPYLENGYNQ 410 NYGRKFVQGK 420 SIDVACHPGY 430 ALPKAQTTVT 440 CMENGWSPTP 450 RCIRVKTCSK 460 SSIDIENGFI 470 SESQYTYALK 480 EKAKYQCKLG 490 YVTADGETSG 500 SITCGKDGWS 510 AQPTCIKSCD 520 IPVFMNARTK 530 NDFTWFKLND 540 TLDYECHDGY 550 ESNTGSTTGS 560 IVCGYNGWSD 570 LPICYERECE 580 LPKIDVHLVP 590 DRKKDQYKVG 600 EVLKFSCKPG 610 FTIVGPNSVQ 620 CYHFGLSPDL 630 PICKEQVQSC 640 GPPPELLNGN 650 VKEKTKEEYG 660 HSEVVEYYCN 670 PRFLMKGPNK 680 IQCVDGEWTT 690 LPVCIVEEST 700 CGDIPELEHG 710 WAQLSSPPYY 720 YGDSVEFNCS 730 ESFTMIGHRS 740 ITCIHGVWTQ 750 LPQCVAIDKL 760 KKCKSSNLII 770 LEEHLKNKKE 780 FDHNSNIRYR 790 CRGKEGWIHT 800 VCINGRWDPE 810 VNCSMAQIQL 820 CPPPPQIPNS 830 HNMTTTLNYR 840 DGEKVSVLCQ 850 ENYLIQEGEE 860 ITCKDGRWQS 870 IPLCVEKIPC 880 SQPPQIEHGT 890 INSSRSSQES 900 YAHGTKLSYT 910 CEGGFRISEE 920 NETTCYMGKW 930 SSPPQCEGLP 940 CKSPPEISHG 950 VVAHMSDSYQ 960 YGEEVTYKCF 970 EGFGIDGPAI 980 AKCLGEKWSH 990 PPSCIKTDCL 1000 SLPSFENAIP 1010 MGEKKDVYKA 1020 GEQVTYTCAT 1030 YYKMDGASNV 1040 TCINSRWTGR 1050 PTCRDTSCVN 1060 PPTVQNAYIV 1070 SRQMSKYPSG 1080 ERVRYQCRSP 1090 YEMFGDEEVM 1100 CLNGNWTEPP 1110 QCKDSTGKCG 1120 PPPPIDNGDI 1130 TSFPLSVYAP 1140 ASSVEYQCQN 1150 LYQLEGNKRI 1160 TCRNGQWSEP 1170 PKCLHPCVIS 1180 REIMENYNIA 1190 LRWTAKQKLY 1200 SRTGESVEFV 1210 CKRGYRLSSR 1220 SHTLRTTCWD 1230 GKLEYPTCAK R

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0106139 symbiont cell surface
Molecular Function GO:0001851 complement component C3b binding
Molecular Function GO:0043395 heparan sulfate proteoglycan binding
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0022010 central nervous system myelination
Biological Process GO:0006956 complement activation
Biological Process GO:0006957 complement activation, alternative pathway
Biological Process GO:0006954 inflammatory response
Biological Process GO:0006508 proteolysis
Biological Process GO:0030449 regulation of complement activation
Biological Process GO:0030451 regulation of complement activation, alternative pathway
Biological Process GO:1903659 regulation of complement-dependent cytotoxicity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.